Strictly, diuresis is increased urine flow and diuretics are substances which elicit diuresis. By this definition, water is a diuretic. In medicine, however, “diuretic” has come to have a more specific meaning. In the kidney, water reabsorption is dependent primarily on Na+ reabsorption and the term diuretic is generally used to mean an agent which inhibits tubular Na+ reabsorption. With the exception of osmotic diuretics (see below), most diuretics are organic acids and hence are secreted by the proximal tubule organic acid secretory mechanism and exert their effects from within the tubule.
KeywordsProximal Tubule Loop Diuretic Thiazide Diuretic Distal Tubule Carbonic Anhydrase Inhibitor
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