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Immunoglobulins and Laboratory Recognition of Monoclonal Proteins

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Abstract

Plasma cell proliferative disorders such as multiple myeloma, macroglobulinemia, and primary amyloidosis are characterized by the clonal expansion of plasma cells and their secreted monoclonal immunoglobulin. The monoclonal immunoglobulin serves as a tumor marker for the recognition of the clinical disorder as well as for monitoring disease progression, response, or relapse. Because of the wide range of biology amongst the plasma cell proliferative diseases, the recognition of a monoclonal protein may require a simple laboratory test or may require multiple approaches. Knowledge of immunoglobulin structure and genetics as well as the technologies of protein electrophoresis, immunoelectrophoresis, and quantitative free light chain (FLC) assessment is needed to fully understand the use of these markers of plasma cell proliferative disease.

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Authors and Affiliations

  1. Department of Lab Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Jerry Katzmann Ph.D. & Melissa Snyder Ph.D.

  2. Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Robert A. Kyle M.D., John Lust M.D. & Angela Dispenzieri M.D.

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  1. Jerry Katzmann Ph.D.
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  2. Robert A. Kyle M.D.
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  3. John Lust M.D.
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  4. Melissa Snyder Ph.D.
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  5. Angela Dispenzieri M.D.
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Correspondence to Jerry Katzmann Ph.D. .

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Editors and Affiliations

  1. Beth Israel Hospital, Cancer Center, St. Lukes-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Peter H. Wiernik

  2. , Department of Hematology, Imperial College of London, Du Cane Road 150, London, W12 0NN, United Kingdom

    John M. Goldman

  3. Continuum Cancer Centers, Department of Medicine, St. Luke's-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Janice P. Dutcher

  4. , Division of Hematology, Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Robert A. Kyle

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Katzmann, J., Kyle, R.A., Lust, J., Snyder, M., Dispenzieri, A. (2013). Immunoglobulins and Laboratory Recognition of Monoclonal Proteins. In: Wiernik, P., Goldman, J., Dutcher, J., Kyle, R. (eds) Neoplastic Diseases of the Blood. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3764-2_29

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