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Epidemiology and Hereditary Aspects of Acute Leukemia

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Neoplastic Diseases of the Blood

Abstract

Recent projections for the United States (USA) estimate that 5,760 patients are diagnosed annually with acute lymphocytic leukemia (ALL) and 12,810 with acute myeloid leukemia (AML), while approximately 1,400 patients die from ALL and 5,170 from AML [1]. Together these forms of acute leukemia represent about 1.3 % of all newly diagnosed cancers and 1.2 % of all cancer deaths in the USA [1]. Advances in understanding of immunology and molecular/genetic features of the acute leukemias along with laboratory improvements in immunophenotyping and cytogenetic characterization have led to the recognition of molecularly defined subtypes of ALL and AML, targeted therapeutics, and recognition of distinct prognostic groups. The most recent World Health Organization (WHO) classification of hematopoietic malignancies considers three major categories of acute leukemia: AML and related myeloid precursor neoplasms, precursor lymphoid neoplasms (encompassing the entities previously known as ALL), and acute leukemias of ambiguous lineage [2]. Consistent with classifications used in cancer registries, to date most epidemiologic investigations have considered all acute leukemias combined or the broad categories of ALL and AML, with only a few evaluating epidemiologic features or risk factors according to molecular subtypes [3–5].

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Authors and Affiliations

  1. Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm. 7048, Rockville, MD, 20852, USA

    Martha S. Linet M.D., M.P.H.

  2. Department of Veterans Affairs Medical Center, Hematology/Oncology, Medical Service, 921 NE, 13th Street, Oklahoma City, OK, 73104, USA

    Graça M. Dores M.D., M.P.H.

  3. Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm. 7051, Rockville, MD, 20852, USA

    Clara J. Kim M.P.H.

  4. Biostatistics Branch, National Cancer Institute, 6120 Executive Blvd, Rm. 8048, Bethesda, MD, 20852, USA

    Susan S. Devesa Ph.D.

  5. Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm. 7040, Rockville, MD, 20852, USA

    Lindsay M. Morton Ph.D.

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  1. Martha S. Linet M.D., M.P.H.
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  2. Graça M. Dores M.D., M.P.H.
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Editors and Affiliations

  1. Beth Israel Hospital, Cancer Center, St. Lukes-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Peter H. Wiernik

  2. , Department of Hematology, Imperial College of London, Du Cane Road 150, London, W12 0NN, United Kingdom

    John M. Goldman

  3. Continuum Cancer Centers, Department of Medicine, St. Luke's-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Janice P. Dutcher

  4. , Division of Hematology, Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Robert A. Kyle

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Linet, M.S., Dores, G.M., Kim, C.J., Devesa, S.S., Morton, L.M. (2013). Epidemiology and Hereditary Aspects of Acute Leukemia. In: Wiernik, P., Goldman, J., Dutcher, J., Kyle, R. (eds) Neoplastic Diseases of the Blood. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3764-2_15

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