Skip to main content
Book cover

Tinnitus pp 121–135Cite as

The Inferior Colliculus: Involvement in Hyperactivity and Tinnitus

  • Chapter
  • First Online:

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 44))

Abstract

This chapter addresses several broad issues regarding the role of the inferior colliculus (IC) in tinnitus:

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Andersen RA, Snyder RL, Merzenich MM (1980) The topographic organization of corticocollicular projections from physiologically identified loci in the AI, AII, and anterior auditory cortical fields of the cat. Journal of Comparative Neurology 191(3):479–494

    Article  PubMed  CAS  Google Scholar 

  • Anderson LA, Malmierca MS, Wallace MN, Palmer AR (2006) Evidence for a direct, short latency projection from the dorsal cochlear nucleus to the auditory thalamus in the guinea pig. European Journal of Neuroscience 24(2):491–498

    Article  PubMed  CAS  Google Scholar 

  • Bauer CA, Turner JG, Caspary DM, Myers KS, Brozoski TJ (2008) Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma. Journal of Neuroscience Research 86(11):2564–2578

    Article  PubMed  CAS  Google Scholar 

  • Brozoski TJ, Bauer CA (2005) The effect of dorsal cochlear nucleus ablation on tinnitus in rats. Hearing Research 206(1–2):227–236

    Article  PubMed  Google Scholar 

  • Brozoski TJ, Bauer CA, Caspary DM (2002) Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus. Journal of Neuroscience 22(6):2383–2390

    PubMed  CAS  Google Scholar 

  • Brozoski TJ, Ciobanu L, Bauer CA (2007) Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI). Hearing Research 228(1–2): 168–179

    Article  PubMed  Google Scholar 

  • Chase SM, Young ED (2005) Limited segregation of different types of sound localization information among classes of units in the inferior colliculus. Journal of Neuroscience 25(33): 7575–7585

    Article  PubMed  CAS  Google Scholar 

  • Chen GD, Jastreboff PJ (1995) Salicylate-induced abnormal activity in the inferior colliculus of rats. Hearing Research 82(2):158–178

    Article  PubMed  CAS  Google Scholar 

  • Davis KA, Ramachandran R, May BJ (1999) Single-unit responses in the inferior colliculus of decerebrate cats. II Sensitivity to interaural level differences Journal of Neurophysiology 82(1):164–175

    CAS  Google Scholar 

  • Dong S, Mulders WH, Rodger J, Robertson D (2009) Changes in neuronal activity and gene expression in guinea-pig auditory brainstem after unilateral partial hearing loss. Neuroscience 159(3):1164–1174

    Article  PubMed  CAS  Google Scholar 

  • Dong S, Mulders WH, Rodger J, Woo S, Robertson D (2010a) Acoustic trauma evokes hyperactivity and changes in gene expression in guinea-pig auditory brainstem. European Journal of Neuroscience 31(9):1616–1628

    PubMed  Google Scholar 

  • Dong S, Rodger J, Mulders WH, Robertson D (2010b) Tonotopic changes in GABA receptor expression in guinea pig inferior colliculus after partial unilateral hearing loss. Brain Research 1342:24–32

    Article  PubMed  CAS  Google Scholar 

  • Eggermont JJ (2006) Cortical tonotopic map reorganization and its implications for treatment of tinnitus. Acta Oto-laryngologica Supplementum 556:9–12

    Article  PubMed  Google Scholar 

  • Finlayson PG, Kaltenbach JA (2009) Alterations in the spontaneous discharge patterns of single units in the dorsal cochlear nucleus following intense sound exposure. Hearing Research 256(1–2):104–117

    Article  PubMed  Google Scholar 

  • Irvine DR, Rajan R, Smith S (2003) Effects of restricted cochlear lesions in adult cats on the frequency organization of the inferior colliculus. Journal of Comparative Neurology 467(3):354–374

    Article  PubMed  Google Scholar 

  • Izquierdo MA, Gutierrez-Conde PM, Merchan MA, Malmierca MS (2008) Non-plastic reorganization of frequency coding in the inferior colliculus of the rat following noise-induced hearing loss. Neuroscience 154(1):355–369

    Article  PubMed  CAS  Google Scholar 

  • Jastreboff PJ, Sasaki CT (1986) Salicylate-induced changes in spontaneous activity of single units in the inferior colliculus of the guinea pig. Journal of the Acoustical Society of America 80(5):1384–1391

    Article  PubMed  CAS  Google Scholar 

  • Jastreboff PJ, Brennan JF, Coleman JK, Sasaki CT (1988) Phantom auditory sensation in rats: An animal model for tinnitus. Behavioral Neuroscience 102(6):811–822

    Article  PubMed  CAS  Google Scholar 

  • Jastreboff, P. J., Nquyen, Q., Brennan, J. F., & Sasaki, C. T. (1992). Calcium and calcium channel involvement in tinnitus. In J-M. Aran & R. Dauman R (Eds.), Tinnitus 91 (pp. 109–114). Proceedings IV International Tinnitus Seminar, Bordeaux, France, 1991. Amsterdam: Kugler.

    Google Scholar 

  • Ma WL, Hidaka H, May BJ (2006) Spontaneous activity in the inferior colliculus of CBA/J mice after manipulations that induce tinnitus. Hearing Research 212(1–2):9–21

    Article  PubMed  Google Scholar 

  • Malmierca MS, Hernandez O, Rees A (2005) Intercollicular commissural projections modulate neuronal responses in the inferior colliculus. European Journal of Neuroscience 21(10):2701–2710

    Article  PubMed  Google Scholar 

  • Montoya P, Ritter K, Huse E, Larbig W, Braun C, Topfner S et al (1998) The cortical somatotopic map and phantom phenomena in subjects with congenital limb atrophy and traumatic amputees with phantom limb pain. European Journal of Neuroscience 10(3):1095–1102

    Article  PubMed  CAS  Google Scholar 

  • Moore BC, Vinay, & Sandhya.(2010). The relationship between tinnitus pitch and the edge frequency of the audiogram in individuals with hearing impairment and tonal tinnitus. Hearing Research 261(1–2):51–56

    Article  PubMed  Google Scholar 

  • Morest DK, Oliver DL (1984) The neuronal architecture of the inferior colliculus in the cat: Defining the functional anatomy of the auditory midbrain. Journal of Comparative Neurology 222(2):209–236

    Article  PubMed  CAS  Google Scholar 

  • Mulders WH, Robertson D (2009) Hyperactivity in the auditory midbrain after acoustic trauma: Dependence on cochlear activity. Neuroscience 164(2):733–746

    Article  PubMed  CAS  Google Scholar 

  • Mulders WH, Seluakumaran K, Robertson D (2010) Efferent pathways modulate hyperactivity in inferior colliculus. Journal of Neuroscience 30(28):9578–9587

    PubMed  CAS  Google Scholar 

  • Norena A, Micheyl C, Chery-Croze S, Collet L (2002) Psychoacoustic characterization of the tinnitus spectrum: Implications for the underlying mechanisms of tinnitus. Audiology and Neurotology 7(6):358–369

    Article  PubMed  Google Scholar 

  • Oliver D (2005) Neuronal organization in the inferior colliculus. In: Winer J, Schreiner C (eds) the inferior colliculus. Springer, New York, pp 69–114

    Chapter  Google Scholar 

  • Patuzzi R, Robertson D (1988) Tuning in the mammalian cochlea. Physiological Reviews 68(4):1009–1082

    PubMed  CAS  Google Scholar 

  • Paul AK, Lobarinas E, Simmons R, Wack D, Luisi JC, Spernyak J et al (2009) Metabolic imaging of rat brain during pharmacologically-induced tinnitus. NeuroImage 44(2):312–318

    Article  PubMed  CAS  Google Scholar 

  • Rajan R, Irvine DR, Wise LZ, Heil P (1993) Effect of unilateral partial cochlear lesions in adult cats on the representation of lesioned and unlesioned cochleas in primary auditory cortex. Journal of Comparative Neurology 338(1):17–49

    Article  PubMed  CAS  Google Scholar 

  • Ramachandran R, Davis KA, May BJ (1999) Single-unit responses in the inferior colliculus of decerebrate cats. I Classification based on frequency response maps Journal of Neurophysiology 82(1):152–163

    CAS  Google Scholar 

  • Rhode WS, Smith PH (1986) Physiological studies on neurons in the dorsal cochlear nucleus of cat. Journal of Neurophysiology 56(2):287–307

    PubMed  CAS  Google Scholar 

  • Robertson D, Irvine DR (1989) Plasticity of frequency organization in auditory cortex of guinea pigs with partial unilateral deafness. Journal of Comparative Neurology 282(3):456–471

    Article  PubMed  CAS  Google Scholar 

  • Shore SE, Koehler S, Oldakowski M, Hughes LF, Syed S (2008) Dorsal cochlear nucleus responses to somatosensory stimulation are enhanced after noise-induced hearing loss. European Journal of Neuroscience 27(1):155–168

    Article  PubMed  CAS  Google Scholar 

  • Sun W, Lu J, Stolzberg D, Gray L, Deng A, Lobarinas E, Salvi RJ (2009) Salicylate increases the gain of the central auditory system. Neuroscience 159(1):325–334

    Article  PubMed  CAS  Google Scholar 

  • Syka J, Popelar J, Kvasnak E, Astl J (2000) Response properties of neurons in the central nucleus and external and dorsal cortices of the inferior colliculus in guinea pig. Experimental Brain Research 133(2):254–266

    Article  CAS  Google Scholar 

  • Wang J, Ding D, Salvi RJ (2002) Functional reorganization in chinchilla inferior colliculus associated with chronic and acute cochlear damage. Hearing Research 168(1–2):238–249

    Article  PubMed  Google Scholar 

  • Winer JA, Larue DT, Diehl JJ, Hefti BJ (1998) Auditory cortical projections to the cat inferior colliculus. Journal of Comparative Neurology 400(2):147–174

    Article  PubMed  CAS  Google Scholar 

  • Winter IM, Palmer AR (1990) Responses of single units in the anteroventral cochlear nucleus of the guinea pig. Hearing Research 44(2–3):161–178

    Article  PubMed  Google Scholar 

  • Young ED, Robert JM, Shofner WP (1988) Regularity and latency of units in ventral cochlear nucleus: Implications for unit classification and generation of response properties. Journal of Neurophysiology 60(1):1–29

    PubMed  CAS  Google Scholar 

  • Zacharek MA, Kaltenbach JA, Mathog TA, Zhang J (2002) Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: Implications for the origin of noise induced tinnitus. Hearing Research 172(1–2):137–143

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the Action on Hearing Loss (RNID) and The University of Western Australia.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Donald Robertson .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media New York

About this chapter

Cite this chapter

Robertson, D., Mulders, W. (2012). The Inferior Colliculus: Involvement in Hyperactivity and Tinnitus. In: Eggermont, J., Zeng, FG., Popper, A., Fay, R. (eds) Tinnitus. Springer Handbook of Auditory Research, vol 44. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3728-4_6

Download citation

Publish with us

Policies and ethics