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The Role of Tumor Exosomes in Tumorigenicity

  • Huang-Ge Zhang
  • Johan K. O. Skog
Chapter

Abstract

Tumor growth and metastasis is dependent on a complex interplay between the tumor cells and the tumor stroma as well as tumor-tumor interaction. This communication occurs through direct interaction, secreted factors as well as microvesicles carrying proteins and nucleic acids. The tumor microvesicles carry a wide range of cargo, including oncogenic proteins, fragmented DNA, mRNA and non-coding RNA with regulatory functions that can be horizontallytransferred between different cells. In addition, these microvesicles are enriched in retrotransposable elements that have been implicated with genetic instability and transcriptional dysregulation.

Keywords

Transposable Element Horizontal Gene Transfer Recipient Cell Phorbol Myristate Acetate Extracellular Matrix Metalloproteinase Inducer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Huang-Ge Zhang
    • 1
  • Johan K. O. Skog
    • 2
  1. 1.James Brown Cancer CenterUniversity of LouisvilleLouisvilleUSA
  2. 2.Exosome Diagnostics Inc.The Lasker Biomedical Research BuildingNew YorkUSA

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