Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth



Tumor formation is not a cell autonomous phenomenon, but rather an evolution of disease within and responding to the host environment. In particular, metastatic spread from a primary tumor results from a complex interplay between tumor cells and the host. In order to form successful metastases, tumor cells must escape the primary tumor, enter the host vasculature, travel to and arrest in a distant tissue and survive and grow in that new organ. Cells that progress through these stages must both escape and exploit host systems.


Melanoma Cell Metastatic Cell B16F1 Cell Pulmonary Vasculature Squamous Cell Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We would like to thank Kyle MacLean for his assistance with figure design. JMK is the recipient of a Translational Breast Cancer Studentship from the London Regional Cancer Program. AFC is a Cancer Research Chair in Oncology and receives salary support from the Canada Research Chairs Program.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Medical BiophysicsUniversity of Western OntarioLondonCanada
  2. 2.Departments of Oncology, Medical Biophysics, and PathologyUniversity of Western OntarioLondonCanada

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