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Experimental and Clinical Metastasis pp 11–27Cite as

Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth

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Abstract

Tumor formation is not a cell autonomous phenomenon, but rather an evolution of disease within and responding to the host environment. In particular, metastatic spread from a primary tumor results from a complex interplay between tumor cells and the host. In order to form successful metastases, tumor cells must escape the primary tumor, enter the host vasculature, travel to and arrest in a distant tissue and survive and grow in that new organ. Cells that progress through these stages must both escape and exploit host systems.

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Acknowledgements

We would like to thank Kyle MacLean for his assistance with figure design. JMK is the recipient of a Translational Breast Cancer Studentship from the London Regional Cancer Program. AFC is a Cancer Research Chair in Oncology and receives salary support from the Canada Research Chairs Program.

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Authors and Affiliations

  1. Department of Medical Biophysics, University of Western Ontario, London, ON, Canada

    Jennifer M Kirstein

  2. Departments of Oncology, Medical Biophysics, and Pathology, University of Western Ontario, London, ON, Canada

    Ann F. Chambers PhD

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  1. Jennifer M Kirstein
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  2. Ann F. Chambers PhD
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Correspondence to Ann F. Chambers PhD .

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Editors and Affiliations

  1. Centre for Genomic Regulation, N/A, Barcelona, N/A, Spain

    Julia V. Burnier

  2. , Ophthalmology, Pathology, Medicine & Onc, McGill University Health Centre, University Street 3775, Montreal, H3A 2B4, Québec, Canada

    Miguel N. Burnier, Jr.

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Kirstein, J., Chambers, A. (2013). Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth. In: Burnier, J., Burnier, Jr., M. (eds) Experimental and Clinical Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3685-0_2

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