Mutant p53-Driven Tumorigenesis



Most tumors inactivate the p53 tumor suppressor pathway via single nucleotide changes of the TP53 gene itself, which produces proteins with missense mutations. p53 mutant proteins clearly lose normal p53 activities. Some are partial loss of function mutations that retain some activities and probably cooperate with other changes in the p53 pathway to initiate tumor development. Many p53 mutants also exhibit gain-of-function and dominant negative properties. Several mouse models with p53 missense mutations have been generated and these now offer opportunities to study the effects of chemotherapeutic modalities.


TP53 Mutation Dominant Negative Dominant Negative Activity IARC TP53 Database TP53 Missense Mutation 
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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of Colorado DenverAuroraUSA
  2. 2.Center for Regenerative Medicine and Stem Cell Biology, University of Colorado DenverAuroraUSA
  3. 3.Department of GeneticsUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

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