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Biochemical Roles of Eukaryotic Cell Surface Macromolecules pp 97–115Cite as

Interactions Between Caveolin-1 and Sphingolipids, and Their Functional Relevance

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 749))

Abstract

Caveolin-1 (CAV-1) is the pivot of a very complex network of interactions that are able to regulate the composition of CAV-1-signaling complexes, the lateral organization of CAV-1 with other molecules within the plasma membrane and the equilibrium between different cellular pools of CAV-1, switching on and off CAV-1- mediated biological events depending on the specific context. The role of sphingolipids in this scenario is very important: sphingolipids can affect CAV-1-mediated biological events due to their multifaceted liaison with caveolin-1. In this review, we discuss the role of CAV-1 as a molecular organizer and in particular we focus on the influence of sphingolipids on this role.

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Abbreviations

CAV-1:

Caveolin-1

DRM:

Detergent-resistant membrane fraction(s)

EGFR:

Epidermal growth factor receptor

EM:

Electron microscopy

HPTLC:

High performance thin layer chromatography

IR:

Insulin receptor

PDGFR:

Platelet-derived growth factor receptor

TNFα:

Tumor necrosis factor α

Ganglioside and glycosphingolipid nomenclature is in accordance with Svennerholm (1980) and the IUPAC–IUBMB recommendations (1998)

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Acknowledgments

This work was supported by AIRC grant 2008 to S.S. and by FIRST 2009 grant to A.P., V.C. and S.S.

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Authors and Affiliations

  1. Department of Medical Chemistry, Biochemistry and Biotechnology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Segrate, 20090, Italy

    Sandro Sonnino, Simona Prioni, Vanna Chigorno & Alessandro Prinetti

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  3. Vanna Chigorno
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  4. Alessandro Prinetti
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Correspondence to Alessandro Prinetti .

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  1. Riverside Transit Campus, School of Biological Sciences, Central University of Kerala, Kasargod, 671328, Kerala, India

    Perumana R. Sudhakaran

  2. National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, Delhi, India

    Avadhesha Surolia

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© 2012 Springer Science+Business Media, LLC

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Sonnino, S., Prioni, S., Chigorno, V., Prinetti, A. (2012). Interactions Between Caveolin-1 and Sphingolipids, and Their Functional Relevance. In: Sudhakaran, P., Surolia, A. (eds) Biochemical Roles of Eukaryotic Cell Surface Macromolecules. Advances in Experimental Medicine and Biology, vol 749. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3381-1_8

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