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Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery

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Biochemical Roles of Eukaryotic Cell Surface Macromolecules

Part of the book series: Advances in Experimental Medicine and Biology ((volume 749))

Abstract

Evidence indicates that blood group-related Lewis (Le) antigens (glycosphingolipids: GSLs and Glycoproteins: GPs) are tumor-associated cell surface molecules. The Lea, Leb, LeX, LeY, and their sialosyl-derivatives, all N-acetylglucosaminyl-containing glycoconjugate antigens, are overexpressed on the surfaces of breast, colon, and ovarian cancer cells during metastasis. A few inhibitors of GSLs (l-/d-PPMP) and DNA (cisplatin) biosynthesis, betulinic acid (a herbal origin of a triterpenoid used for cancer treatment in China), melphalan, and disialosylgangliosides (GD3 and GD1b) induced apoptosis (intrinsic mitochondrial or extrinsic receptor-mediated pathways) in human breast (SKBR-3, MCF-7, and MDA-468) and colon (Colo-205) cells. These chemicals are suggested to be potential anticancer drugs. In this review, we try to compare our recent observations with reported observations from many other laboratories. We discuss the induction of apoptosis in breast and other cancer cells by various new chemicals. We also discuss the biosynthesis and regulation of GSLs in nonapoptotic and apoptotic cancer cells.

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Acknowledgment

We thank Mrs. Doris Ann Nielsen and Mr. Eric Kuehner for their help during preparation of this manuscript.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry and Cancer Drug Delivery Research Foundation, University of Notre Dame, 752, Notre Dame, IN, 46556, USA

    Subhash Basu & Manju Basu

  2. Siemens, 2297, Elkhart, IN, 46515, USA

    Rui Ma

  3. The Falk Center for Molecular Therapeutics, Northwestern University, Evanston, IL, 60201, USA

    Joseph R. Moskal

  4. Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH, 44129, USA

    Sipra Banerjee

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  1. Subhash Basu
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  2. Rui Ma
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  3. Joseph R. Moskal
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  4. Manju Basu
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Correspondence to Subhash Basu .

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  1. Riverside Transit Campus, School of Biological Sciences, Central University of Kerala, Kasargod, 671328, Kerala, India

    Perumana R. Sudhakaran

  2. National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, Delhi, India

    Avadhesha Surolia

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Basu, S., Ma, R., Moskal, J.R., Basu, M., Banerjee, S. (2012). Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery. In: Sudhakaran, P., Surolia, A. (eds) Biochemical Roles of Eukaryotic Cell Surface Macromolecules. Advances in Experimental Medicine and Biology, vol 749. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3381-1_16

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