Protective Effect of Acupuncture on Myocardium

Chapter

Abstract

Perioperative myocardial ischemia–reperfusion, pulmonary interstitial edema, and postoperative central nervous system complications are the main risk factors that affect the postoperative rehabilitation of patients who have undergone cardiac surgery. Based on the principle of “where there is a meridian acupoint, there is the indication,” we have selected two points of pericardium meridian of hand-Jue Yin [Neiguan (PC-6)] and lung meridian of hand-Tai Yin [Yunmen (LU-2), Lieque (lU-7)] to strengthen prevention and protection of perioperative myocardial ischemia, reduce perioperative risk factors effectively, and improve patient’s postoperative rehabilitation through regulation of body’s internal environment. The regulation mechanisms of circulatory function by acupuncture include (1) cardiac autoresuscitation rate, incidence of myocardial ischemia, vasoactive drug dosage, incidence of postoperative complications, ICU, and hospital stay days for cardiac surgery patients to whom the acupuncture anesthesia were significantly better than patients with endotracheal intubation anesthesia. (2) The studies show that the acupuncture anesthesia for cardiac surgery has reduced operative risk and improved surgical safety. Its main mechanisms include (a) regulation of β-EP, ACTH, cortisol, and plasma dopamine by electroacupuncture stimulation that improve impact of surgery on internal environment; (b) increase HSP70 expression by myocardial cells; (c) reduce mitochondrial membrane permeability; (d) inhibit cell adhesion process so as to reduce myocardial cell injury. (3) According to the principle of “where there is a meridian acupoint, there is the indication,” we find that double points selection of lung meridian of hand-Tai Yin [Yunmen (LU-2), Lieque (lU-7)] has apparent effect on myocardial protection, suggesting local and remote synergy of acupoints along meridians. Acupuncture anesthesia is a combined technique, including acupuncture combined with hypothermic anesthesia, and acupuncture anesthesia combined drugs (salvia, nicardipine, l-arginine) which have a synergistic effect on circulation regulation.

Keywords

Acupuncture anesthesia Myocardial ischemia–reperfusion Cardiopulmonary bypass Cardiac protection Immune regulation 

Notes

Acknowledgments

This work was supported by the following grants: (1) Chinese Ministry of Science and Technology (973) 2007CB512504: Basic research of specificity of acupoints based on clinical acupuncture anesthesia; (2) National Natural Science Foundation of China (39670898): Protection of myocardium by electroacupuncture stimulation during open heart surgery; (3) Ministry of Health (Research Grant No.: 96-1-342): In vivo protection of myocardium by acupuncture during open heart surgery; (4) National Natural Science Foundation 2000-2002 (39970921): Protective effect of acupuncture-assisted hypothermia anesthesia on myocardial ischemia–reperfusion; (5) Ministry of Health (98-2-314): Myocardial protective effect of acupuncture-assisted hypothermia anesthesia on patients undergoing cardiac surgery; (6) Science and Technology Commission of Shanghai Municipality (05DZ19746): Clinical study of acupuncture; and (7) Science and Technology Commission of Shanghai Municipality (Grant No.: 07DZ19722-4): Effect of moderate activation of mast cells mediated ROS-HIF pathway in myocardial protection with acupuncture anesthesia and its mechanism.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Anesthesiology and Pain Management, Renji HospitalShanghai JiaoTong University School of MedicineShanghaiChina

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