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Pathophysiology of Insulin Resistance: Implications for Prevention

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Prevention of Type 2 Diabetes

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Abstract

Insulin resistance is a condition in which there is decreased ability of insulin to stimulate glucose disposal by muscle, adipose tissue, and liver. Insulin resistance (IR) is characterized by decreasing sensitivity of target tissues to the action of insulin, elevated blood glucose concentration, and increased hepatic production of atherogenic lipids. IR is associated with declining insulin production by the pancreas, the emergence of T2DM, and increasing risk of cardiovascular disease (CVD).

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Authors and Affiliations

  1. Department of Medicine, Section of Endocrinology, Tulane University Health Science Center, 1430 Tulane Avenue, SL-53, New Orleans, LA, 70112, USA

    Shamsa Ali MD & Vivian A. Fonseca MD, FRCP

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  1. Shamsa Ali MD
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  2. Vivian A. Fonseca MD, FRCP
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Correspondence to Vivian A. Fonseca MD, FRCP .

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  1. , Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, 10029, USA

    Derek LeRoith

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Ali, S., Fonseca, V.A. (2012). Pathophysiology of Insulin Resistance: Implications for Prevention. In: LeRoith, D. (eds) Prevention of Type 2 Diabetes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3314-9_3

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  • DOI: https://doi.org/10.1007/978-1-4614-3314-9_3

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