Abstract
NIRS is ideally suited to perform brain imaging in various populations during movement as it represents several advantages over other methods (Perrey, Methods 45:289–299, 2008). Thus, it is not surprising that the last two decades have witnessed a considerable increase in the use of NIRS with healthy subjects and patients. This chapter first outlines typical hemodynamic changes measured with NIRS in responses to different exercise demands. Then, we describe its future prospective in neuroimaging clinical studies with emphasis on the fact that although there are still many problems to solve, the potential benefits of NIRS are considerable for obtaining further insights into brain functions during exercise.
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References
Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF, Dempsey JA (2006) Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575:937–952
Bhambhani Y, Malik R, Mookerjee S (2007) Cerebral oxygenation declines at exercise intensities above the respiratory compensation threshold. Respir Physiol Neurobiol 156:196–202
Bigland-Ritchie B, Furbush F, Woods JJ (1986) Fatigue of intermittent submaximal voluntary contractions: central and peripheral factors. J Appl Physiol 61:421–429
Dalsgaard MK (2006) Fuelling cerebral activity in exercising man. J Cereb Blood Flow Metab 26:731–750
Dalsgaard MK, Secher NH (2007) The brain at work: a cerebral metabolic manifestation of central fatigue? J Neurosci Res 85:3334–3339
Derosieres G, Perrey S (2012) Relationship between submaximal handgrip muscle force and NIRS-measured motor cortical activation. Adv Exp Med Biol 737:269–274
Gandevia SC (2001) Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81:1725–1789
González-Alonso J, Dalsgaard MK, Osada T, Volianitis S, Dawson EA, Yoshiga CC, Secher NH (2004) Brain and central haemodynamics and oxygenation during maximal exercise in humans. J Physiol 557:331–342
Hansen AJ (1985) Effect of anoxia on ion distribution in the brain. Physiol Rev 65:101–148
Harada T, Miyai I, Suzuki M, Kubota K (2009) Gait capacity affects cortical activation patterns related to speed control in the elderly. Exp Brain Res 193:445–454
Hirth C, Obrig H, Villringer K, Thiel A, Bernarding J, Mühlnickel W, Flor H, Dirnagl U, Villringer A (1996) Non-invasive functional mapping of the human motor cortex using near-infrared spectroscopy. Neuroreport 7:1977–1981
Ide K, Horn A, Secher NH (1999) Cerebral metabolic response to submaximal exercise. J Appl Physiol 87:1604–1608
Jöbsis FF (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198(4323):1264–1267
Jørgensen LG (1995) Transcranial Doppler ultrasound for cerebral perfusion. Acta Physiol Scand Suppl 625:1–44
Kleinschmidt A, Obrig H, Requardt M, Merboldt KD, Dirnagl U, Villringer A, Frahm J (1996) Simultaneous recording of cerebral blood oxygenation changes during human brain activation by magnetic resonance imaging and near-infrared spectroscopy. J Cereb Blood Flow Metab 16:817–826
Kono T, Matsuo K, Tsunashima K, Kasai K, Takizawa R, Rogers MA, Yamasue H, Yano T, Taketani Y, Kato N (2007) Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men. Neurosci Res 57:504–512
Madsen PL (1993) Blood flow and oxygen uptake in the human brain during various states of sleep and wakefulness. Acta Neurol Scand Suppl 148:3–27
Maki A, Yamashita Y, Ito Y, Watanabe E, Mayanagi Y, Koizumi H (1995) Spatial and temporal analysis of human motor activity using noninvasive NIR topography. Med Phys 22:1997–2005
Millet GY, Lepers R (2004) Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sports Med 34:105–116
Miyai I, Tanabe HC, Sase I, Eda H, Oda I, Konishi I, Tsunazawa Y, Suzuki T, Yanagida T, Kubota K (2001) Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 14:1186–1192
Miyai I, Fujimoto Y, Yamamoto H, Ueda Y, Saito T, Nozaki S, Kang J (2002) Long-term effect of body weight-supported treadmill training in Parkinson’s disease: a randomized controlled trial. Arch Phys Med Rehabil 83:1370–1373
Miyai I, Yagura H, Hatakenaka M, Oda I, Konishi I, Kubota K (2003) Longitudinal optical imaging study for locomotor recovery after stroke. Stroke 34:2866–2870
Miyai I, Suzuki M, Hatakenaka M, Kubota K (2006) Effect of body weight support on cortical activation during gait in patients with stroke. Exp Brain Res 169:85–91
Neary PJ, Roberts AD, Leavins N, Harrison MF, Croll JC, Sexsmith JR (2008) Prefrontal cortex oxygenation during incremental exercise in chronic fatigue syndrome. Clin Physiol Funct Imaging 28:364–372
Nielsen HB, Boushel R, Madsen P, Secher NH (1999) Cerebral desaturation during exercise reversed by O2 supplementation. Am J Physiol 277:H1045–H1052
Nybo L, Rasmussen P (2007) Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise. Exerc Sport Sci Rev 35:110–118
Obrig H, Hirth C, Junge-Hülsing JG, Döge C, Wolf T, Dirnagl U, Villringer A (1996) Cerebral oxygenation changes in response to motor stimulation. J Appl Physiol 81:1174–1183
Orgogozo JM, Larsen B (1979) Activation of the supplementary motor area during voluntary movement in man suggests it works as a supramotor area. Science 206:847–850
Pereira MI, Gomes PS, Bhambhani YN (2007) A brief review of the use of near infrared spectroscopy with particular interest in resistance exercise. Sports Med 37:615–624
Perrey S (2008) Non-invasive NIR spectroscopy of human brain function during exercise. Methods 45:289–299
Racinais S, Girard O, Micallef JP, Perrey S (2007) Failed excitability of spinal motoneurons induced by prolonged running exercise. J Neurophysiol 97:596–603
Rasmussen P, Dawson EA, Nybo L, van Lieshout JJ, Secher NH, Gjedde A (2007) Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J Cereb Blood Flow Metab 27:1082–1093
Rasmussen P, Nielsen J, Overgaard M, Krogh-Madsen R, Gjedde A, Secher NH, Petersen NC (2010) Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol 588:1985–1995
Ross EZ, Middleton N, Shave R, George K, Nowicky A (2007) Corticomotor excitability contributes to neuromuscular fatigue following marathon running in man. Exp Physiol 92:417–426
Rupp T, Perrey S (2008) Prefrontal cortex oxygenation and neuromuscular responses to exhaustive exercise. Eur J Appl Physiol 102:153–163
Rupp T, Perrey S (2009) Effect of severe hypoxia on prefrontal cortex and muscle oxygenation responses at rest and during exhaustive exercise. Adv Exp Med Biol 645:329–334
Saitou H, Yanagi H, Hara S, Tscuchiya S, Tomura S (2000) Cerebral blood flow and oxygenation among poststroke hemiplegic patients: effects of 13 rehabilitation tasks measured by near-infrared spectroscopy. Arch Phys Med Rehab 81:1348–1356
Shibuya K, Kuboyama N (2007) Human motor cortex oxygenation during exhaustive pinching task. Brain Res 1156:120–124
Shibuya K, Tanaka J, Kuboyama N, Murai S, Ogaki T (2004a) Cerebral cortex activity during supramaximal exhaustive exercise. J Sports Med Phys Fitness 44:215–219
Shibuya K, Tanaka J, Kuboyama N, Ogaki T (2004b) Cerebral oxygenation during intermittent supramaximal exercise. Respir Physiol Neurobiol 140:165–172
Shibuya K, Sadamoto T, Sato K, Moriyama M, Iwadate M (2008) Quantification of delayed oxygenation in ipsilateral primary motor cortex compared with contralateral side during a unimanual dominant-hand motor task using near-infrared spectroscopy. Brain Res 1210:142–147
Sirikul B, Hunter GR, Larson-Meyer DE, Desmond R, Newcomer BR (2007) Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction. Appl Physiol Nutr Metab 32:394–399
Subudhi AW, Dimmen AC, Roach RC (2007) Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol 103:177–183
Subudhi AW, Miramon BR, Granger ME, Roach RC (2009) Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol 106:1153–1158
Suzuki M, Miyai I, Ono T, Oda I, Konishi I, Kochiyama T, Kubota K (2004) Prefrontal and premotor cortices are involved in adapting walking and running speed on the treadmill: an optical imaging study. Neuroimage 23:1020–1026
Suzuki M, Miyai I, Ono T, Kubota K (2008) Activities in the frontal cortex and gait performance are modulated by preparation. An fNIRS study. Neuroimage 39:600–607
Timinkul A, Kato M, Omori T, Deocaris CC, Ito A, Kizuka T, Sakairi Y, Nishijima T, Asada T, Soya H (2008) Enhancing effect of cerebral blood volume by mild exercise in healthy young men: a near-infrared spectroscopy study. Neurosci Res 61:242–248
Wolf M, Ferrari M, Quaresima V (2007) Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications. J Biomed Opt 12:062104
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Perrey, S. (2012). NIRS for Measuring Cerebral Hemodynamic Responses During Exercise. In: Boecker, H., Hillman, C., Scheef, L., Strüder, H. (eds) Functional Neuroimaging in Exercise and Sport Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3293-7_14
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DOI: https://doi.org/10.1007/978-1-4614-3293-7_14
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