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What are the Potential Future Treatments in Antiphospholipid Syndrome?

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Abstract

Persistently positive antiphospholipid antibodies (aPL) in association with thromboses and/or pregnancy morbidity is the hallmark of the antiphospholipid syndrome (APS). The management of aPL-positive patients has been focused on utilizing traditional antithrombotic medications, such as heparin or warfarin. Given that our understanding of the molecular mechanisms of aPL-mediated thrombosis has been growing, this chapter reviews potential “immunomodulatory” approaches (tissue factor inhibition, P38 mitogen-activated protein kinase inhibition, nuclear factor-κB inhibition, platelet glycoprotein receptor inhibition, hydroxychloroquine, statins, inhibition of b2-glycoprotein-I β2GPI and/or anti-β2 GPI binding to target cells, complement inhibition, and B cell inhibition) as well as new oral thrombin and factor Xa inhibitors that will most likely have an important future role in the management of aPL-positive patients.

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Authors and Affiliations

  1. The Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medical College of Cornell University, 535 E. 70th St., New York, NY, 10021, USA

    Doruk Erkan MD

  2. Centre for Rheumatology, University College London, London, UK

    Anisur Rahman PhD

  3. Department of Haematology, University College London Hospitals, NHS Foundation Trust, London, UK

    Hannah Cohen MD, FRCP

  4. Department of Haematology, University College London Hospitals, London, UK

    Samuel J. Machin MB, ChB

  5. Division of Rheumatology, Department of Internal Medicine, Microbiology and Pathology, University of Texas Medical Branch, Galveston, TX, USA

    Silvia S. Pierangeli PhD

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  1. Doruk Erkan MD
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  2. Anisur Rahman PhD
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  3. Hannah Cohen MD, FRCP
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  4. Samuel J. Machin MB, ChB
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  5. Silvia S. Pierangeli PhD
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Correspondence to Doruk Erkan MD .

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Editors and Affiliations

  1. The Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, New York, NY, USA

    Doruk Erkan

  2. University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555-0883, Texas, USA

    Silvia S. Pierangeli

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Erkan, D., Rahman, A., Cohen, H., Machin, S.J., Pierangeli, S.S. (2012). What are the Potential Future Treatments in Antiphospholipid Syndrome?. In: Erkan, D., Pierangeli, S. (eds) Antiphospholipid Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-3194-7_18

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