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Glioma pp 26–40Cite as

Recent Medical Management of Glioblastoma

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 746))

Abstract

This chapter contains an overview of standard of care and experimental chemotherapy treatments for glioblastoma multiforme (GBM). We discuss the role of alkylating agents, focusing primarily on temozolomide (TMZ) which, in combination with radiation therapy, is part of the standard of care treatment for newly diagnosed GBM. TMZ has proven both well tolerated and effective in prolonging patient survival, but tumor recurrence remains the rule. We review the development and use of molecularly targeted agents, low molecular weight kinase inhibitors and monoclonal antibodies that interrupt the signaling pathways exploited by tumors to grow, migrate and avoid apoptosis.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA

    Derek R. Johnson & Susan M. Chang

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  1. Derek R. Johnson
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  2. Susan M. Chang
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Correspondence to Susan M. Chang .

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  1. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Ryuya Yamanaka MD, PhD

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Johnson, D.R., Chang, S.M. (2012). Recent Medical Management of Glioblastoma. In: Yamanaka, R. (eds) Glioma. Advances in Experimental Medicine and Biology, vol 746. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3146-6_3

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