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Biodegradable Mg Alloys: Corrosion, Surface Modification, and Biocompatibility

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Biomedical Applications

Part of the book series: Modern Aspects of Electrochemistry ((MAOE,volume 55))

Abstract

Metallic materials used in biomedical applications traditionally are highly corrosion resistant, in order to prevent degradation of permanent implants and to diminish possibly harmful metal ion release. Therefore, metallic materials used for instance in orthopaedic applications include Ti base alloys, stainless steels, or Co–Cr–Mo alloys. As these materials are passive in the human body, only a quite small amount of metal ions is released into the surroundings by electrochemical corrosion. A very different approach is the use of low-corrosion-resistant metals for biodegradable, temporary implants. Biodegradable (or bioabsorbable) implants are of interest for applications, in which from medical point of view the implant is not required to stay in the body permanently. An example of such an application is stenting, where remodeling of the arterial wall is expected to take place and a continuous presence of the stent becomes unnecessary. For biodegradable metals, once implanted, the device would stay in human body only for the time it takes to heal, and then it will spontaneously dissolve away. Permanent metallic implants can lead to certain biocompatibility problems related to continuous physical/mechanical irritation and long-term release of metallic ions and/or particles through corrosion or wear processes. Moreover, implantation in children would require an additional surgery in order to remove the permanent implant which cannot adapt to growth of the human body. Such problems could be avoided using a bioabsorbable implant.

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References

  1. Hermawan H, Dubé D, Mantovani D (2010) Acta Biomater 6:1693

    Article  CAS  Google Scholar 

  2. Moravej M, Mantovani D (2011) Int J Mol Sci 12:4250

    Article  CAS  Google Scholar 

  3. Schinhammer M, Hänzi AC, Löffler JF, Uggowitzer PJ (2010) Acta Biomater 6:1705

    Article  CAS  Google Scholar 

  4. Hänzi AC, Sologubenko AS, Uggowitzer PJ (2009) Int J Mater Res 100:1127

    Article  Google Scholar 

  5. Hänzi AC, Dalla Torre FH, Sologubenko AS, Gunde P, Schmid-Fetzer R, Kuehlein M, Löffler JF, Uggowitzer PJ (2009) Philos Mag Lett 89:377

    Article  Google Scholar 

  6. Staiger MP, Pietak AM, Huadmai J, Dias G (2006) Biomaterials 27:1728

    Article  CAS  Google Scholar 

  7. Heublein B, Rohde R, Kaese V, Niemeyer M, Hartung W, Haverich A (2003) Heart 89:651

    Article  CAS  Google Scholar 

  8. Witte F (2010) Acta Biomater 6:1680

    Article  CAS  Google Scholar 

  9. Witte F, Hort N, Vogt C, Cohen S, Kainer KU, Willumeit R, Feyerabend F (2008) Curr Opin Solid State Mater Sci 12:68

    Article  Google Scholar 

  10. Virtanen S, (2011) Mater Sci Eng B 176:1600–1608

    Google Scholar 

  11. Xin Y, Hub T, Chu PK (2011) Acta Biomater 7:1452

    Article  CAS  Google Scholar 

  12. Song GL, Atrens A (1999) Adv Eng Mater 1:11

    Article  CAS  Google Scholar 

  13. Song GL, Atrens A (2003) Adv Eng Mater 5:837

    Article  CAS  Google Scholar 

  14. Song GL, Atrens A (2007) Adv Eng Mater 9:177

    Article  CAS  Google Scholar 

  15. Pourbaix M (1974) Atlas of electrochemical equilibria in aqueous solutions, 2nd edn. NACE, Houston

    Google Scholar 

  16. Quach N-C, Uggowitzer PJ, Schmutz P (2008) CR Chimie 11:1043

    Article  CAS  Google Scholar 

  17. Lorenz C, Brunner JG, Kollmannsberger P, Jaafar L, Fabry B, Virtanen S (2009) Acta Biomater 5:2783

    Article  CAS  Google Scholar 

  18. Seuss F, Seuss S, Can Turhan M, Fabry B, Virtanen S (2011) J Biomed Mater Res B 99B:276–281

    Google Scholar 

  19. Mueller W-D, Lucia Nascimento M, Fernández Lorenzo M (2010) de Mele. Acta Biomater 6:1749

    Article  CAS  Google Scholar 

  20. Xin Y, Hu T, Chu PK (2010) J Electrochem Soc 157:C238

    Article  CAS  Google Scholar 

  21. Witte F, Fischer J, Nellesen J, Crostack H-A, Kaese V, Pisch A, Beckmann F, Windhagen H (2006) Biomaterials 27:1013

    Article  CAS  Google Scholar 

  22. Liu M, Uggowitzer PJ, Nagasekhar AV, Schmutz P, Easton M, Song G-L, Atrens A (2009) Corros Sci 51:602

    Article  CAS  Google Scholar 

  23. Südholz AD, Kirkland NT, Buchheit RG, Birbilis N (2011) Electrochem Solid-State Lett 14:C5

    Article  Google Scholar 

  24. Kirkland NT, Lespagnol J, Birbilis N, Staiger MP (2010) Corros Sci 52:287

    Article  CAS  Google Scholar 

  25. Müller L, Müller FA (2006) Acta Biomater 2:181

    Article  Google Scholar 

  26. Oyane A, Kim HM, Furya T, Kokubo T, Miyazaki T, Nakamura T (2003) J Biomed Mater Res 65A:188

    Article  CAS  Google Scholar 

  27. Xin Y, Hub T, Chu PK (2011) Corros Sci 53:1522

    Article  CAS  Google Scholar 

  28. Mueller W-F, de Mele MFL, Nascimento ML, Zeddier M (2009) J Biomed Mater Res 90A:487

    Article  CAS  Google Scholar 

  29. Liu C, Xin Y, Tian X, Chu PK (2007) J Mater Res 22:1806

    Article  CAS  Google Scholar 

  30. Liu CL, Wang YJ, Zheng RC, Zhang XM, Huang WJ, Chu PK (2010) Corros Sci 52:3341

    Article  CAS  Google Scholar 

  31. Rettig R, Virtanen S (2008) J Biomed Mater Res 85A:167

    Article  CAS  Google Scholar 

  32. Gu XN, Zheng YF, Chen LJ (2009) Biomed Mater 4:1

    Google Scholar 

  33. Yamamoto A, Hiromoto S (2009) Mater Sci Eng C 29:1559

    Article  CAS  Google Scholar 

  34. Rettig R, Virtanen S (2009) J Biomed Mater Res 88A:359

    Article  CAS  Google Scholar 

  35. Keim S, Brunner JG, Fabry B, Virtanen S (2011) J Biomed Mater Res B 96:84

    Google Scholar 

  36. Xin Y, Huo K, Tao H, Tang G, Chu PK (2008) Acta Biomater 4:2008

    Article  CAS  Google Scholar 

  37. Li L, Gao J, Wang Y (2004) Surf CoatTechnol 185:92

    Article  CAS  Google Scholar 

  38. Zhang Y, Tao H-R, He YH, Zou G-Y, Jian Y, Zhang S-X, Zhang B-L, Li J-N, Zhao C-L, Zhang X-N (2008) J Clin Rehabil Tissue Eng 12:8162–8166

    CAS  Google Scholar 

  39. Gu X, Zheng Y, Cheng Y, Zhong S, Xi T (2009) Biomaterials 30:484

    Article  CAS  Google Scholar 

  40. Zhang E, Yin D, Xu L, Yang L, Yang K (2009) Mater Sci Eng C 29:987

    Article  CAS  Google Scholar 

  41. Zhang S, Li J, Song Y, Zhao C, Zhang X, Xie C, Zhang Y, Tao H, He Y, Jiang Y, Bian Y (2009) Mater Sci Eng C 29:1907

    Article  CAS  Google Scholar 

  42. Yun Y, Dong Z, Yang D, Schulz MJ, Shanov VN, Yarmolenko S, Xu Z, Kumta P, Sfeir C (2009) Mater Sci Eng C 29:1814

    Article  CAS  Google Scholar 

  43. Xin Y, Jiang J, Huo K, Tang G, Tian X, Chu PK (2009) J Biomed Mater Res A 89:717

    Google Scholar 

  44. Fischer J, Prosenc MH, Wolff M, Hort N, Willumeit R, Feyerabend F (2010) Acta Biomater 6:1813

    Article  CAS  Google Scholar 

  45. Gray JE, Luan B (2002) J Alloys Compd 336:88

    Article  CAS  Google Scholar 

  46. Chen XB, Birbilis N, Abbot TB (2011) Corrosion 67:03005–1

    Article  Google Scholar 

  47. Yang J, Cui F, Lee IS (2011) Ann Biomed Eng 39:1857

    Article  Google Scholar 

  48. Narayanan R, Seshadri SK, Kwon TY, Kim KH (2008) J Biomed Mater Res 85B:279

    Article  CAS  Google Scholar 

  49. Yang JX, Jiao YP, Cui FZ, Lee I-S, Yin QS, Zhang Y (2008) Surf Coat Technol 202:5733

    Article  CAS  Google Scholar 

  50. Song YW, Shan DY, Han EH (2008) Mater Lett 62:3276

    Article  CAS  Google Scholar 

  51. Hiromoto S, Shishido T, Yamamoto A, Maruyama N, Somekawa H, Mukai T (2008) Corros Sci 50:2906

    Article  CAS  Google Scholar 

  52. Zhang Y, Zhang G, Wei M (2008) J Biomed Mater Res 89B:408

    Article  Google Scholar 

  53. Geng F, Tan LL, Jin XX, Yang JY, Yang K (2009) J Mater Sci Mater Med 20:1149

    Article  CAS  Google Scholar 

  54. Wen C, Guan S, Peng L, Ren C, Wang X, Hu Z (2009) Appl Surf Sci 255:6433

    Article  CAS  Google Scholar 

  55. Wang Y, Wei M, Gao J (2009) Mater Sci Eng C 29:1311

    Article  CAS  Google Scholar 

  56. Xu L, Pan F, Yu G, Yang L, Zhang E, Yang K (2009) Biomaterials 30:1512

    Article  CAS  Google Scholar 

  57. Cortes DA, Lopez HY, Mantovani D (2007) Mater Sci Forum 539–543:589

    Article  Google Scholar 

  58. Hiromoto S, Yamamoto A (2009) Electrochim Acta 54:7085

    Article  CAS  Google Scholar 

  59. Gray-Munro JE, Strong M (2009) J Biomed Mater Res 90A:339

    Article  CAS  Google Scholar 

  60. Tomozawa M, Hiromoto S, Harada Y (2010) Surf Coat Technol 204:3243

    Article  CAS  Google Scholar 

  61. Chen X-B, Birbilis N, Abbott TB (2011) Corros Sci 53:2263

    Article  CAS  Google Scholar 

  62. Waterman J, Pietak A, Birbilis N, Woodfield T, Dias G, Staiger MP (2011) Mater Sci Eng B 176:1756–1760

    Google Scholar 

  63. Pietak A, Shadanbaz S, Walker J, Staiger MP, Dias GJ, Mater Sci Eng B (in press)

    Google Scholar 

  64. Roy A, Singh SS, Datta MK, Lee B, Ohodnicki J, Kumta PN (2011) Mater Sci Eng B 176:1679

    Article  CAS  Google Scholar 

  65. Song Y, Zhang S, Li J, Zhao C, Zhang X (2010) Acta Biomater 6:1736

    Article  CAS  Google Scholar 

  66. Ono S, Kijima H, Masuko N (2002) J Surf Finish Soc Jpn 53:406 (in Japanese)

    Article  CAS  Google Scholar 

  67. Hiromoto S, Yamamoto A (2010) Mater Sci Eng C 30:1085

    Article  CAS  Google Scholar 

  68. Peixoto Barbosa D, Knörnschild G (2009) Surf Coat Technol 203:1629

    Article  CAS  Google Scholar 

  69. Sul YT (2003) Biomaterials 24:3893

    Article  CAS  Google Scholar 

  70. Sul YT, Johansson C, Byon E, Albrektsson T (2005) Biomaterials 26:6720

    Article  CAS  Google Scholar 

  71. Ren L, Lin X, Tan L, Yang K (2011) Mater Lett 65:3509

    Article  CAS  Google Scholar 

  72. Chiu KY, Wong MH, Cheng FT, Man HC (2007) Surf Coat Technol 202:590

    Article  CAS  Google Scholar 

  73. Yan T, Tan L, Xiong D, Liu X, Zhang B, Yang K (2010) Mater Sci Eng C 30:740

    Article  CAS  Google Scholar 

  74. Drynda A, Hassel T, Hoehn R, Perz A, Bach F-W, Peuster M (2010) J Biomed Mater Res A 93:763

    Google Scholar 

  75. Pereda MD, Alonso C, Burgos-Asperilla L, Del Valle JA, Ruano OA, Perez P, Fernández Lorenzo De Mele MA (2010) Acta Biomater 6:1772

    Article  CAS  Google Scholar 

  76. Witte F, Fischer J, Nellesen J, Vogt C, Vogt J, Donath T, Beckmann F (2010) Acta Biomater 6:1792

    Article  CAS  Google Scholar 

  77. Ye X-Y, Chen M-F, You C, Liu D-B (2010) Front Mater Sci China 4:132

    Article  Google Scholar 

  78. Scott A, Gray-Munro JE (2009) Thin Solid Films 517:6809

    Article  CAS  Google Scholar 

  79. Scott AF, Gray-Munro JE, Shepherd JL (2010) J Colloid Interface Sci 343:474

    Article  CAS  Google Scholar 

  80. Liu Y, Yu Z, Zhou S, Wu L (2006) Appl Surf Sci 252:3818

    Article  CAS  Google Scholar 

  81. Ishizaki T, Okido M, Masuda Y, Saito N, Sakamoto M (2011) Langmuir 27:6009

    Article  CAS  Google Scholar 

  82. Ishizaki T, Teshima K, Masuda Y, Sakamoto M (2011) J Colloid Interface Sci 360:280.s

    Article  Google Scholar 

  83. Wang Y-H, Zhong L, Liu Y-Y, Jiang Q-L, Guo X-Y, Wang J (2010) Corros Sci Prot Technol 22:329

    CAS  Google Scholar 

  84. Killian M, Wagener V, Schmuki P, Virtanen S (2010) Langmuir 26:12044

    Article  CAS  Google Scholar 

  85. Gray-Munro JE, Seguin C, Strong M (2009) J Biomed Mater Res 91A:221

    Article  CAS  Google Scholar 

  86. Wong HM, Yeung KWK, Lam KO, Tam V, Chu PK, Luk KDK, Cheung KMC (2010) Biomaterials 31:2084

    Article  CAS  Google Scholar 

  87. Gu XN, Zheng YF, Lan QX, Cheng Y, Zhang ZX, Xi FT, Zhang DY, Biomed Mater 4 (2009) Article number 044109

    Google Scholar 

  88. Li JN, Cao P, Zhang XN, Zhang SX, He YH (2010) J Mater Sci 45:6038

    Article  CAS  Google Scholar 

  89. Lu P, Fan H, Liu Y, Cao L, Wu X, Xu X (2011) Colloids Surf B Biointerfaces 83:23

    Article  CAS  Google Scholar 

  90. Williams G, Grace R (2011) Electrochim Acta 56:1894

    Article  CAS  Google Scholar 

  91. Park J, Bauer S, von der Mark K, Schmuki P (2007) Nano Lett 7:1686

    Article  CAS  Google Scholar 

  92. Tsuchiya H, Macak JM, Müller L, Kunze J, Müller F, Greil P, Virtanen S, Schmuki P (2006) J Biomed Mater Res A 77A:534

    Article  CAS  Google Scholar 

  93. Brunner J, Hahn R, Kunze J, Virtanen S (2009) J Electrochem Soc 156:C62

    Article  CAS  Google Scholar 

  94. Turhan MC, Lynch RP, Jha H, Schmuki P, Virtanen S (2010) Electrochem Commun 12:796

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Materials Science and Engineering (WW-4), Institute for Surface Science and Corrosion, University of Erlangen-Nuremberg, Martensstrasse 7, Erlangen, 91058, Germany

    Sannakaisa Virtanen

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  1. Sannakaisa Virtanen
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Correspondence to Sannakaisa Virtanen .

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  1. Elchem Consulting Ltd., 103 Str. NW 15511, Edmonton, T5X 6B3, Alberta, Canada

    Stojan S. Djokić

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Virtanen, S. (2012). Biodegradable Mg Alloys: Corrosion, Surface Modification, and Biocompatibility. In: Djokić, S. (eds) Biomedical Applications. Modern Aspects of Electrochemistry, vol 55. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-3125-1_3

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