Abstract
The risk of cerebrovascular disease increases with advanced age, with almost two thirds of individuals over 70 exhibiting vascular lesions on MRI. Cognitive presentations vary from little or no no cognitive impairment to clinical dementia, and the extent of cognitive impairment is not necessarily correlated with lesion size or burden. The term vascular cognitive impairment (VCI) describes all forms of cognitive impairment caused by cerebrovascular disease. Early identification of vascular disease is critical since many risk factors are modifiable, and the neuropsychologist can play an important role in characterizing the extent of cognitive and behavioral change. This chapter provides an overview of the clinical guidelines to consider when evaluating older adults with possible VCI and includes an illustrative case example and useful recommendations for the clinician.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
O’Brien JT, Erkinjuntti T, Reisberg B, et al. Vascular cognitive impairment. Lancet Neurol. 2003;2:89–98.
Sadowski M, Pankiewicz J, Sholtzava H, et al. Links between the pathology of Alzheimer’s disease and vascular dementia. Neurochem Res. 2004;29(6):1257–66.
Hachinski VC, Lliff D, Zihlka E, et al. Cerebral blood flow in dementia. Arch Neurol. 1975;32(9):632–7.
Wentzel C, Rockwood K, MacKnight C, et al. Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology. 2001;57(4):714–6.
Williamson JB, Nyenhuis DL, Pedelty L, et al. Baseline differences between vascular cognitive impairment reverters and nonreverters. J Neurol Neurosurg Psychiatry. 2008;79(11):1208–14.
Williams M. Progress in Alzheimer’s disease drug discovery: an update. Curr Opin Investig Drugs. 2009;10(1):23–34.
Ingles JL, Wentzel C, Fisk JD, Rockwood K. Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, no dementia. Stroke. 2002;33:1999–2002.
Garrett KD, Browndyke JN, Whelihan W, Paul RH, DiCarlo M, Moser DJ, et al. The neuropsychological profile of vascular cognitive impairment—no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia. Arch Clin Neuropsychol. 2004;19:745–57.
Nyenhuis DL, Gorelick PB, Geenen EJ, et al. The pattern of neuropsychological deficits in vascular cognitive impairment—no dementia (Vascular CIND). Clin Neuropsychol. 2004;18(1):41–9.
Jokinen H, Kalska H, Mantyla R, et al. Cognitive profile of subcortical ischaemic vascular disease. J Neurol Neurosurg Psychiatry. 2006;77:28–33.
Traykov L, Baudic S, Rauox N, et al. Patterns of memory impairment and perseverative behavior discriminate early Alzheimer’s disease from subcortical vascular dementia. J Neurol Sci. 2005;229–230:75–9.
Wallin A, Milos V, Sjogren M, Pantoni L, Erkinjuntti T. Classification and subtypes of vascular dementia. Int Psychogeriatr. 2003;15(1):27–37.
Robinson RG, Spalleta G. Poststroke depression: a review. Can J Psychiatry. 2010;55(6):341–9.
American Psychiatric Association Committee on Nomenclature and Statistics. Diagnostic and statistical manual of mental disorders (DSM-IV). 4th ed. Washington, DC: American Psychiatric Association; 1994.
Chui HC, Victoroff JI, Margolin D, Jagust W, Shankle R, Katzman R. Criteria for the diagnosis of ischemic vascular dementia proposed by the state of California Alzheimer’s Disease Diagnostic and Treatment Centers. Neurology. 1992;42:473–80.
Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology. 1993;43:250–60.
Cosentino SA, Jefferson AL, Carey ME, et al. The clinical diagnosis of vascular dementia: a comparison among four classification systems and a proposal for a new paradigm. Clin Neuropsychol. 2004;18(1):6–21.
Goldstein LB, Bushnell CD, Adams RJ, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:1–68.
Guidetti D, Casali B, Mazzei RL, Dotti MT. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Clin Exp Hypertens. 2006;28:271–7.
Hajjar I, Sorond F, Hsu Y-H, Galica A, Cupples LA, Lipsitz LA. Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston study. Stroke. 2010;41:635–40.
Ogino A, Kazui H, Miyoshi N, et al. Cognitive impairment in patients with idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Disord. 2006;21(2):113–9.
Factora R, Luciano M. When to consider normal pressure hydrocephalus in the patient with gait disturbance. Geriatrics. 2008;63(2):32–7.
Paul R, Garrett K, Cohen R. Vascular dementia: a diagnostic conundrum for the clinical neuropsychologist. Appl Neuropsychol. 2003;10(3):129–36.
Chui H, Gontheir R. Natural history of vascular dementia. Alzheimer Dis Assoc Disord. 1999;13:S124–30.
O’Sullivan M, Morris RG, Markus HS. Brief cognitive assessment for patients with cerebral small vessel disease. J Neurol Neurosurg Psychiatry. 2005;76(8): 1140–5.
Pachet A, Astner K, Brown L. Clinical utility of the mini-mental status examination when assessing decision-making capacity. J Geriatr Psychiatry Neurol. 2010;23(1):3–8.
Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.
Hachinski V, Iadecola C, Petersen RC, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006;37(9):2220–41.
Canning SJ, Leach L, Stuss D, Ngo L, Black SE. Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia. Neurology. 2004;62(4):556–62.
Henry JD, Crawford JR, Phillips LH. Verbal fluency performance in dementia of the Alzheimer’s type: a meta-analysis. Neuropsychologia. 2004;42(9): 1212–22.
Jefferson AL, Cahn-Weiner D, Boyle P, Paul RH, Gordon N, Moser D, Cohen RA. Cognitive predictors of changes in activities of daily living among patients with vascular dementia. Int J Geriatr Psychiatry. 2006;21(8):752–4.
Jefferson AL, Paul RH, Ozonoff A, Cohen RA. Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs). Arch Clin Neuropsychol. 2006;21(4): 311–20.
De Coene B, Hajnal JV, Gatehouse P, et al. MR of the brain using fluid-attenuated inversion recovery (FLAIR) pulse sequences. Am J Neuroradiol. 1992;13(6):1555–64.
Kamada K, Kakeda S, Ohnari N, Moriya J, Sato T, Korogi Y. Signal intensity of motor and sensory cortices on T2-weighted and FLAIR images: intraindividual comparison of 1.5T and 3T MRI. Eur Radiol. 2008;18(12):2949–55. Epub 2008 Jul 19.
Stankiewicz JM, Glanz BI, Healy BC, et al. Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. J Neuroimaging. 2011;21(2): e50–6.
Price CC, Jefferson AL, Merino JG, Heilman KM, Libon DJ. Subcortical vascular dementia: integrating neuropsychological and neuroradiological data. Neurology. 2005;65(3):376–82.
Boone KB, Miller BL, Lesser IM, et al. Neuropsychological correlates of white matter lesions in healthy elderly subjects: a threshold effect. Arch Neurol. 1992;49:549–54.
Seno H, Ishino H, Inagaki T, Yamamori C, Miyaoaka T. Comparison between multiple lacunar infarcted patients with and without dementia in nursing homes in shimane prefecture, Japan. Dement Geriatr Cogn Disord. 2000;11:161–5.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Paul, R., Lane, E., Jefferson, A. (2013). Vascular Cognitive Impairment. In: Ravdin, L., Katzen, H. (eds) Handbook on the Neuropsychology of Aging and Dementia. Clinical Handbooks in Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3106-0_19
Download citation
DOI: https://doi.org/10.1007/978-1-4614-3106-0_19
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-3105-3
Online ISBN: 978-1-4614-3106-0
eBook Packages: Behavioral ScienceBehavioral Science and Psychology (R0)