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NanoCellBiology of Secretion

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NanoCellBiology of Secretion

Part of the book series: SpringerBriefs in Biological Imaging ((BRIEFSBIOIMAG))

Abstract

Cells synthesize, store, and secrete, on demand, products such as hormones, growth factors, neurotransmitters, or digestive enzymes. Cellular cargos destined for secretion are packaged and stored in membranous sacs or vesicles, which are transported via microtubule and actin railroad systems, to dock and establish continuity at the base of specialized cup-shaped plasma membrane structures called porosomes to release their contents. The fusion of membrane-bound secretory vesicles at the porosome base, and the molecular mechanism of secretory vesicle swelling required for content expulsion during cell secretion, is discussed in this Springer Brief. These new findings in the last 15 years have resulted in a paradigm shift in our understanding of the secretory process in cells and has given birth to a new field in biology—NanoCellBiology.

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Acknowledgments

The author thanks the students and collaborators who have participated in the various studies discussed in this chapter. Support from the National Institutes of Health (USA), the National Science Foundation (USA), and Wayne State University is greatly appreciated.

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  1. NanoBioScience Institute Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Bhanu P. Jena (Director)

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Correspondence to Bhanu P. Jena .

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Jena, B.P. (2012). NanoCellBiology of Secretion. In: NanoCellBiology of Secretion. SpringerBriefs in Biological Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2438-3_1

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