Effects of Methylmercury on Cellular Signal Transduction Systems

Chapter
Part of the Current Topics in Neurotoxicity book series (Current Topics Neurotoxicity, volume 2)

Abstract

Methylmercury (MeHg) is a major environmental toxicant that affects cellular functions including growth, differentiation, and migration. Dependent upon the cellular context and developmental phase of the cells, various cellular stress responses are induced and cell fate is determined in response to MeHg exposure. MeHg triggers the activation or suppression of cellular signaling pathways in a manner similar to other environmental stressors. Cellular signal transduction systems that are disturbed by MeHg exposure are potential therapeutic targets for MeHg cytotoxicity. This review focuses on the cellular signal transduction systems involved in responses to MeHg exposure, such as mitogen-activated protein kinase cascade, redox signaling pathway, Rho/ROCK signaling pathway, and Notch signaling pathway.

Keywords

Migration Toxicity Mercury Lymphoma Glutathione 

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Copyright information

© Springer Science+Business Media, LLC  2012

Authors and Affiliations

  1. 1.Department of Clinical MedicineNational Institute for Minamata DiseaseMinamata CityJapan
  2. 2.Department of Basic Medical SciencesNational Institute for Minamata DiseaseMinamata CityJapan

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