Effects of Methylmercury on Cellular Signal Transduction Systems
Methylmercury (MeHg) is a major environmental toxicant that affects cellular functions including growth, differentiation, and migration. Dependent upon the cellular context and developmental phase of the cells, various cellular stress responses are induced and cell fate is determined in response to MeHg exposure. MeHg triggers the activation or suppression of cellular signaling pathways in a manner similar to other environmental stressors. Cellular signal transduction systems that are disturbed by MeHg exposure are potential therapeutic targets for MeHg cytotoxicity. This review focuses on the cellular signal transduction systems involved in responses to MeHg exposure, such as mitogen-activated protein kinase cascade, redox signaling pathway, Rho/ROCK signaling pathway, and Notch signaling pathway.
KeywordsNeural Stem Cell Notch Signaling Axonal Degeneration Cellular Stress Response MeHg Exposure
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