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Obesity and Pancreatic Cancer

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Book cover Energy Balance and Gastrointestinal Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 4))

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Abstract

Pancreatic cancer is the fourth leading cause of cancer death for both men and women in the United States. It is a highly fatal disease with a 5-year survival rate of approximately 6%. Obesity, in addition to cigarette smoking and diabetes, is one of the few modifiable risk factors that have been associated with increased risk of pancreatic cancer. Obesity has also been associated with an early onset and reduced survival of pancreatic cancer. Insulin resistance and inflammation are two most anticipated biological mechanisms that link obesity and pancreatic cancer. Because of the high prevalence of overweight or obesity in the U.S. population, a better understanding of the complex association between obesity and pancreatic cancer may provide opportunities for the development of novel strategies in prevention and treatment of this deadly disease. The current epidemiological evidence and potential biological mechanisms involved in the obesity-pancreatic cancer association are reviewed.

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Authors and Affiliations

  1. Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Donghui Li Ph.D.

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  1. Donghui Li Ph.D.
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Correspondence to Donghui Li Ph.D. .

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  1. , Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, 44106, Ohio, USA

    Sanford D. Markowitz

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Li, D. (2012). Obesity and Pancreatic Cancer. In: Markowitz, S., Berger, N. (eds) Energy Balance and Gastrointestinal Cancer. Energy Balance and Cancer, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2367-6_6

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