Cyclooxygenase-2 and Chronic Inflammation: Drivers of Colorectal Tumorigenesis

  • Monica M. Bertagnolli
Part of the Energy Balance and Cancer book series (EBAC, volume 4)


A common feature of the relationship between abnormal energy balance, altered hormonal regulation, and cancer is the presence of increased inflammation. In individuals with obesity-associated metabolic disorder, an increased inflammatory response can be identified on both systemic- and tissue-specific levels. This chapter details the relationship between cyclooxygenase-2 (COX-2), a key mediator of local inflammatory response, and the development of colorectal cancer. It also describes the modulation of COX-2 activity as a means of preventing and treating colorectal tumors. Finally, this chapter addresses new data concerning the role of COX-2 activity in obesity and metabolic syndrome.


Epidermal Growth Factor Receptor Familial Adenomatous Polyposis Colorectal Neoplasia Advanced Adenoma Nonselective NSAID 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Surgical OncologyDana Farber Cancer Institute, Brigham & Women’s Hospital, Harvard Medical SchoolBostonUSA

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