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RAMPs pp 25–37Cite as

Regulation of GPCR Trafficking by RAMPs

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 744))

Abstract

AM and CGRP receptors undergo differential intracellular receptor trafficking upon ligand stimulation. Intracellular trafficking of CLR/RAMP receptor complexes is regulated by posttranslational modifications and protein-protein interactions that differ for each cell type. Recent evidence is accumulating to suggest that the RAMP isoform in complex with CLR may play a role in determining the intracellular trafficking and fate of ligand-stimulated receptor complexes. In this chapter, we will review the current literature on mechanisms of regulating receptor trafficking and roles that have been demonstrated for RAMPs in this regulation.

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Author information

Authors and Affiliations

  1. Department of Physiology, Michigan State University, East Lansing, Michigan, USA

    Jennifer M. Bomberger, Narayanan Parameswaran & William S. Spielman

Authors
  1. Jennifer M. Bomberger
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  2. Narayanan Parameswaran
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  3. William S. Spielman
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Corresponding author

Correspondence to Jennifer M. Bomberger .

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Editors and Affiliations

  1. Department of Physiology, Michigan State University, East Lansing, Michigan, USA

    William S. Spielman PhD  & Narayanan Parameswaran PhD  & 

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Bomberger, J.M., Parameswaran, N., Spielman, W.S. (2012). Regulation of GPCR Trafficking by RAMPs. In: Spielman, W.S., Parameswaran, N. (eds) RAMPs. Advances in Experimental Medicine and Biology, vol 744. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2364-5_3

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