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Multifunctional Nanoparticles for Personalized Medicine

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Multifunctional Nanoparticles for Drug Delivery Applications

Part of the book series: Nanostructure Science and Technology ((NST))

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Abstract

Breakthroughs in genetic sequencing, biomarker discovery, clinical diagnostics, and drug development have led to the ability to diagnose and treat disease in a more individualized manner. Personalized medicine treats each patient as a unique individual and customizes therapy based on the unique disease characteristics of that individual. Personalizing medicine presents a particular challenge and promise in a disease like cancer which is diverse, dynamic, and where treatment is sensitive to disease stage. Multifunctional nanoparticles could play a critical role in the future of personalized medicine, having the versatility to package large quantities of chemotherapeutics and contrast agents, enhance pharmacokinetics of traditional treatments and imaging strategies, and allow specific targeting of diseased tissues both passively and actively. This chapter will focus on the use of multifunctional nanoparticles in the diagnosis, monitoring, and treatment of cancer with specific focus on applications in personalized medicine.

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Acknowledgments

Funding from the National Institutes of Health (NCI, CA 153229), National Science Foundation (CBET 0756567), Georgia Cancer Coalition, Coulter Foundation, and Ian’s Friends Foundation is acknowledged.

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Authors and Affiliations

  1. Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332, USA

    Benjamin T. Roller, Kathleen M. McNeeley & Ravi V. Bellamkonda

Authors
  1. Benjamin T. Roller
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  2. Kathleen M. McNeeley
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  3. Ravi V. Bellamkonda
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Corresponding author

Correspondence to Ravi V. Bellamkonda .

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Editors and Affiliations

  1. Drug Delivery Solutions LLC, Temple Street 16, Arlington, 02476, Massachusetts, USA

    Sonke Svenson

  2. Princeton University, n/a, Princeton, 08544, USA

    Robert K. Prud'homme

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Roller, B.T., McNeeley, K.M., Bellamkonda, R.V. (2012). Multifunctional Nanoparticles for Personalized Medicine. In: Svenson, S., Prud'homme, R. (eds) Multifunctional Nanoparticles for Drug Delivery Applications. Nanostructure Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2305-8_13

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  • DOI: https://doi.org/10.1007/978-1-4614-2305-8_13

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