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Population Structure

  • Chapter
Analysis of Genetic Association Studies

Part of the book series: Statistics for Biology and Health ((SBH))

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Abstract

Population stratification (PS) and correcting for PS are studied in Chap. 9. The chapter starts with an introduction to population structure and its impact on inference using the trend test. Different models of PS are given. Methods to correct for PS are discussed, including genomic control, structural association, principal component clustering , and multidimensional scaling plots. How to select marker loci to correct for PS is discussed. Comparison of the several methods is reported using simulations. How to simulate case-control data in the presence of PS is given.

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Author information

Authors and Affiliations

  1. Bethesda, MD, USA

    Gang Zheng

  2. School of Management, Dept. Statistics & Finance, University of Science & Technology of China, Hefei, Anhui, People’s Republic of China

    Yaning Yang

  3. School of Medicine, Dept. Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, OH, USA

    Xiaofeng Zhu & Robert C. Elston

Authors
  1. Gang Zheng
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  2. Yaning Yang
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  3. Xiaofeng Zhu
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  4. Robert C. Elston
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Correspondence to Gang Zheng .

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© 2012 Springer Science+Business Media, LLC

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Zheng, G., Yang, Y., Zhu, X., Elston, R.C. (2012). Population Structure. In: Analysis of Genetic Association Studies. Statistics for Biology and Health. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2245-7_9

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