Haplotype Analysis for Case-Control Data

  • Gang Zheng
  • Yaning Yang
  • Xiaofeng Zhu
  • Robert C. Elston
Part of the Statistics for Biology and Health book series (SBH)

Abstract

Chapter 7 covers haplotype analysis. It starts with haplotype inference, including an introduction to phase and phase ambiguity and estimation of haplotype frequencies. Haplotype disequilibrium, testing for linkage disequilibrium (LD), haplotype blocks and tagging SNPs are discussed. Two types of tests are considered. The first is haplotype-based association analysis, including the likelihood ratio test, regression method, and haplotype similarity. The second comprise LD contrast tests, including composite LD measures and contrasting LD measures.

Keywords

Covariance Recombination 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Gang Zheng
    • 1
  • Yaning Yang
    • 2
  • Xiaofeng Zhu
    • 3
  • Robert C. Elston
    • 3
  1. 1.BethesdaUSA
  2. 2.School of Management, Dept. Statistics & FinanceUniversity of Science & Technology of ChinaHefeiPeople’s Republic of China
  3. 3.School of Medicine, Dept. Epidemiology & BiostatisticsCase Western Reserve UniversityClevelandUSA

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