Abstract
Gene-environment interactions are considered in Chap. 10, which focuses on a 2×2×2 table. The expressions of odds ratios for the genetic effect, the environmental factor effect, and the gene-environment interaction are given. More general cases for gene and environmental factors are briefly discussed. Three common tests for gene-environment interaction are studied, including the Score test, the likelihood ratio test (LRT) and the Wald test. Examples are given with detailed calculations.
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Zheng, G., Yang, Y., Zhu, X., Elston, R.C. (2012). Gene-Environment Interactions. In: Analysis of Genetic Association Studies. Statistics for Biology and Health. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2245-7_10
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DOI: https://doi.org/10.1007/978-1-4614-2245-7_10
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