Skip to main content

New Approach to Understand the Biology of Stem Cells

  • Chapter
  • First Online:
Induced Pluripotent Stem Cells

Part of the book series: SpringerBriefs in Stem Cells ((BRIEFSSTEM))

  • 1657 Accesses

Abstract

Colebrook (2002) claims that we are in a post-linguistic era and need to develop theories and approaches that are not language dependent. On the other hand, we have been dedicated firmly to use only language to describe extremely complex and interactive events in biology. If we think that mathematics is the language of nature then we should be able to represent and understand everything around us through numbers. When we turn those numbers of any system to the graphs, patterns emerge. Hence, there are patterns everywhere in nature (Aronofsky 1998). The way complex systems and patterns arise out of a multiplicity of relatively simple interactions is called emergence. Therefore, emergence is central to the theories of integrative levels and of complex systems (Corning 2002).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aronofsky D (1998) Pi. USA: 84 minutes.

    Google Scholar 

  • Byrne JA et al (2007) Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature 450(7169):497–502

    Article  PubMed  CAS  Google Scholar 

  • Colebrook C (2002) Understanding Deleuze. Allen and Unwin, Crows Nest

    Google Scholar 

  • Corning PA (2002) The re-emergence of “emergence”: a venerable concept in search of a theory. Complexity 7(6):18–30

    Article  Google Scholar 

  • Goodwin B (1996) How the leopard changed its spots. Touchstone Book, New York

    Google Scholar 

  • Hemberger M et al (2009) Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington’s canal. Nat Rev Mol Cell Biol 10(8):526–537

    Article  PubMed  CAS  Google Scholar 

  • Hochedlinger K, Plath K (2009) Epigenetic reprogramming and induced pluripotency. Development 136(4):509–523

    Article  PubMed  CAS  Google Scholar 

  • Hoffman J (2010) Benoît Mandelbrot, Novel mathematician, Dies at 85. New York Times A28.

    Google Scholar 

  • Huang S (2004) Back to the biology in systems biology: what can we learn from biomolecular networks? Brief Funct Genomic Proteomic 2(4):279–297

    Article  PubMed  CAS  Google Scholar 

  • Huang S (2009) Reprogramming cell fates: reconciling rarity with robustness. Bioessays 31(5):546–560

    Article  PubMed  CAS  Google Scholar 

  • Huang S (2011) Systems biology of stem cells: three useful perspectives to help overcome the paradigm of linear pathways. Philos Trans R Soc Lond B Biol Sci 366(1575):2247–2259

    Article  PubMed  CAS  Google Scholar 

  • Huang S, Wikswo J (2006) Dimensions of systems biology. Rev Physiol Biochem Pharmacol 157:81–104

    PubMed  CAS  Google Scholar 

  • Huang GT et al (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 88(9):792–806

    Article  PubMed  CAS  Google Scholar 

  • Ingold T (1990) An anthropologist looks at biology. Man (NS) 25:208–229

    Google Scholar 

  • Kauffman S (1969) Homeostasis and differentiation in random genetic control networks. Nature 224(5215):177–178

    Article  PubMed  CAS  Google Scholar 

  • Kauffman SA (1993) Self-organization and adaptation in complex system. Oxford University Press, New York

    Google Scholar 

  • Koussoulakou DS et al (2009) A curriculum vitae of teeth: evolution, generation, regeneration. Int J Biol Sci 5(3):226–243

    Article  PubMed  Google Scholar 

  • Lederman L, Teresi D (1993) The god particle if the universe Is the answer, what is the question?. Dell Publishing, New York

    Google Scholar 

  • Oktar PA et al (2011) Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker. Stem Cell Rev 7(2):413–424

    Article  PubMed  Google Scholar 

  • Saha K, Jaenisch R (2009) Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 5(6):584–595

    Article  PubMed  CAS  Google Scholar 

  • Slack JM (2002) Conrad Hal Waddington: the last renaissance biologist? Nat Rev Genet 3(11):889–895

    Article  PubMed  CAS  Google Scholar 

  • Softologyblog (2011) Archive for the ‘Fractals’ category. http://softologyblog.wordpress.com/category/fractals/

  • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663–676

    Article  PubMed  CAS  Google Scholar 

  • Waddington C (1957) The strategy of genes. George Allen & Unwin, London

    Google Scholar 

  • Waddington CH (1959) Canalization of development and genetic assimilation of acquired characters. Nature 183(4676):1654–1655

    Article  PubMed  CAS  Google Scholar 

  • Waddington CH, Robertson E (1966) Selection for developmental canalisation. Genet Res 7(3):303–312

    Article  PubMed  CAS  Google Scholar 

  • Wilmut I et al (2011) The evolving biology of cell reprogramming. Philos Trans R Soc Lond B Biol Sci 366(1575):2183–2197

    Article  PubMed  CAS  Google Scholar 

  • Ying QL et al (2008) The ground state of embryonic stem cell self-renewal. Nature 453(7194):519–523

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sibel Yildirim .

Rights and permissions

Reprints and permissions

Copyright information

© 2012 The Author(s)

About this chapter

Cite this chapter

Yildirim, S. (2012). New Approach to Understand the Biology of Stem Cells. In: Induced Pluripotent Stem Cells. SpringerBriefs in Stem Cells. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2206-8_7

Download citation

Publish with us

Policies and ethics