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Induced Pluripotent Stem Cells pp 5–10Cite as

Pluripotent Cells

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Part of the book series: SpringerBriefs in Stem Cells ((BRIEFSSTEM))

Abstract

The defining properties of ESCs are the ability to proliferate indefinitely without commitment to any cell lineages (self-renewal) and the capacity to differentiate into cell lineages from three germ layers (pluripotency). ESCs were the first pluripotent cells isolated from normal embryos derived from the inner cell mass (ICM) of preimplantation embryos. Mouse ESCs (mESCs) contribute cells to the three germ layers and to the germline of chimeric animals when injected into mouse blastocysts. However, there are distinguishing molecular and biological characteristics between ESCs and their in vivo counterparts of the ICM. Cells of the ICM do not self-renew, and they have globally hypomethylated genome, whereas, ESCs have unlimited proliferation potential and they have characteristically highly methylated genome.

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Authors and Affiliations

  1. Department of Pediatric Dentistry, Faculty of Dentistry, Selcuk University, Konya, Turkey

    Sibel Yildirim

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  1. Sibel Yildirim
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Correspondence to Sibel Yildirim .

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Yildirim, S. (2012). Pluripotent Cells. In: Induced Pluripotent Stem Cells. SpringerBriefs in Stem Cells. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2206-8_2

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