Abstract
Nanotechnology is rapidly evolving and having a widespread impact. Due to the small size and physiochemical nature of nanomaterials, it has been revolutionising advanced medical devices. It is important to note that the World Health Organisation’s definition of medical devices includes examples that are counterintuitive but must be examined, this involves a large range of devices that can be categorised in the fields of imaging, biosensors and surgery. It is also germane to evaluate how academia, industry and government regulations are using legislative protocols to mitigate the associated risks. This chapter intends to review the field of advanced medical devices utilizing nanotechnology together with a discussion on its impact on health and medicine.
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- AFM:
-
Atomic Force Microscopy
- AMD:
-
Advanced Medical Device
- CCMV:
-
Cowpea Chlorotic Mottle Virus
- CT:
-
Computed tomography
- EBID:
-
Electron Beam Induced Deposition
- ECM:
-
Extracellular Matrix
- ESF:
-
European Science Foundation
- HSE:
-
Health and Safety Executive
- LOC:
-
Lab on a Chip
- MD:
-
Medical Device
- MEMs:
-
Microelectromechnical System
- MNP:
-
Magnetic Nanoparticles
- MPA:
-
Mercaptopropionic Acid (MPA)
- MRI:
-
Magnetic Resonance Imaging
- NEMs:
-
Nanoelectromechnical Systems
- NMs:
-
Nanomaterials
- NP:
-
Nanoparticles
- OSHA:
-
Occupational Safety and Health Act
- PAMAM:
-
Poly(amidoamine)
- PB:
-
Prussian Blue
- PEG:
-
Polyethylene Glycol
- PMMA:
-
Polymethyl Methacrylate
- POC:
-
Point of Care
- QD:
-
Quantum Dots
- REACH:
-
Registration Evaluation, Authorisation and restriction of Chemicals
- SPION:
-
Superparamagnetic Iron Oxide Nanoparticles
- SPR:
-
Surface Plasmon Resonance
- SWCNT:
-
Single Walled Carbon Nanotube
- USPION:
-
Ultra-small Superparamagnetic Iron Oxide Nanoparticles
- VNP:
-
Viral Nanoparticles
- WHO:
-
World Health Organisation
References
Zheng J (2014) Layout of nanotechnology patents in global market. Adv Mat Res 889:1578–1584
Hansen SF, Maynard A, Baun A, Tickner JA (2008) Late lessons from early warnings for nanotechnology. Nat Nanotechnol 3:444–447
Flynn T, Wei C (2005) The pathway to commercialization for nanomedicine. Nanomedicine 1(1):47–51
Feynman R (1960) There’s plenty of room at the bottom. Caltech’s Eng Sci 23:22–36
Patel DN, Bailey SR (2007) Nanotechnology in cardiovascular medicine. Catheter Cardiovasc Interv 69:643–654
European Science Foundation (2004) Nanomedicine – an ESF–European Medical Research Councils (EMRC) forward look report, ESF, Strasbourg cedex
Webster TJ (2006) Nanomedicine: what’s in a definition? Ch. 2. Int J Nanomed 1:115–116
World Health Organization (2003) Medical device regulations: global overview and guiding principles. World Health Organization, Geneva
Cheng M (2003) Medical device regulations global overview and guiding principles. WHO, Geneva
Weissleder R, Pittet MJ (2008) Imaging in the era of molecular oncology. Nature 452:580–589
Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17(5):545–580
Jokerst JV, Gambhir SS (2011) Molecular imaging with theranostic nanoparticles. Acc Chem Res 44:1050–1060
Weissleder R, Ross BD, Rehemtulla A, Gambhir SS (2010) Molecular imaging: principles and practice. People’s Medical Publishing House, Shelton
Jamali AA, Pourhassan-Moghaddam M, Dolatabadi JEN, Omidi Y (2014) Nanomaterials on the road to microRNA detection with optical and electrochemical nanobiosensors. TrAC Trend Anal Chem 55:24–42
Liu TY, Lo CL, Huang CC, Lin SL, Chang CA (2014) Engineering nanomaterials for biosensors and therapeutics. In: Cai W (ed) Engineering in translational medicine. Springer, London, pp 513–534
Luong JHT, Male KB, Glennon JD (2008) Biosensor technology: technology push versus market pull. Biotechnol Adv 26:492–500
Privett BJ, Shin JH, Schoenfisch MH (2008) Electrochemical sensors. Anal Chem 80:4499–4517
Pushkarsky I, Tseng P, Murray C, Di Carlo D (2014) Research highlights: microfluidics and magnets. Lab Chip 14:2882–2886
Sung JH, Kama C, Shuler ML (2010) A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip. Lab Chip 10:446–455
Asiyanbola B, Soboyejo W (2008) For the surgeon: an introduction to nanotechnology. J Surg Educ 65:155–161
Rosenthal SJ, McBride J, Pennycook SJ, Feldman LC (2007) Synthesis surface studies, composition and structural characterization of CdSe, core/shell and biologically active nanocrystals. Surf Sci Rep 62:111–157
Michalet XF, Pinaud F, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Quantum dots for live cells in vivo imaging, and diagnostics. Science 307:538–544
Parak WJ, Gerion D, Pellegrino T, Zanche D, Micheel C, Williams SC, Boudreau R, Le Gros MA, Larabell CA, Alivisatos AP (2003) Biological applications of colloidal nanocrystals. Nanotechnology 14:15–27
Akerman ME, Chan WC, Laakkonen P, Bhatia SN, Ruoslahti E (2002) Nanocrystal targeting in vivo. Proc Natl Acad Sci 99:12617–12621
Jaiswal JK, Mattoussi H, Mauro JM, Simon SM (2002) Long-term multiple colour imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 21:47–51
Ye L, Yong K-T, Liu L, Roy I, Hu R, Zhu J, Cai H, Law W-C, Liu J, Wang K, Liu J, Liu Y, Hu Y, Zhang X, Swihart MT, Prasad PN (2012) A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots. Nat Nanotechnol 7:453–458
Mattoussi H, Palui G, Na HB (2012) Luminescent quantum dots as platforms for probing in vitro and in vivo biological processes. Adv Drug Deliv Rev 64:138–166
Na HB, Song IC, Hyeon T (2009) Inorganic nanoparticles for MRI contrast agents. Adv Mater 21:2133–2148
Steinmetz NF (2010) Viral nanoparticles as platforms for next-generation therapeutics and imaging devices. Nanomedicine 6:634–641
Allen M, Bulte JWM, Liepold L, Basu G, Zywicke HA, Frank JA, Young M, Douglas T (2005) Paramagnetic viral nanoparticles as potential high-relaxivity magnetic resonance contrast agents. Magn Reson Med 54:807–812
Sun C, Lee JSH, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:1252–1265
Veiseh O, Gunn JW, Zhang M (2010) Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev 62(3):284–304
Cormode DP, Sanchez-Gaytan BL, Mieszawska AJ, Fayad ZA, Mulder WJM (2013) Inorganic nanocrystals as contrast agents in MRI: synthesis coating and introduction of multifunctionality. NMR Biomed 26:766–780
Gunasakera UA, Pankhurst QA, Douek M (2009) Imaging applications of nanotechnology in cancer. Target Oncol 4:169–181
Lyubchenko YL, Kim BH, Krasnoslobodtsev AV, Yu J (2010) Nanoimaging for protein misfolding diseases. Nanomed Nanobiotechnol 2:526–543
Connelly L, Jang H, Teran Arce F, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R (2012) Atomic force microscopy and MD simulations reveal pore-like structures of all-d-enantiomer of Alzheimer’s β-amyloid peptide: relevance to the ion channel mechanism of AD pathology. J Phys Chem B 116:1728–1735
Burke KA, Yates EA, Legleiter J (2013) Amyloid-forming proteins alter the local mechanical properties of lipid membranes. Biochemistry 52:808–817
Zou Q, Leang KK, Sadoun E, Reed MJ, Devasia S (2004) Control issues in high-speed AFM for biological applications: collagen imaging example. Asian J Control 6:164–178
Voitchovsky K, Contera SA, Kamahira M, Watts A, Ryan JF (2006) Differential stiffness and lipid mobility in the leaflets of purple membranes. Biophys J 90:2075–2085
Yamashita H, Voitchovsky K, Uchihashi T, Contera SA, Ryan JF, Toshio A (2009) Dynamics of bacteriorhodopsin 2D crystal observed by high-speed atomic force microscopy. J Struct Biol 167:153–158
Van Mamaren J, Wuite GJL, Heller I (2011) Introduction to optical tweezers: background system designs, and commercial solutions. Methods Mol Biol 783:1–20
Ermilov SA, Murdock DR, Qian F, Brownell WE, Anvari B (2007) Studies of plasma membrane mechanics and plasma membrane of plasma mem interactions using optical tweezers and fluorescence imaging. J Biomech 40:476–480
Pine J, Chow G (2009) Moving live dissociated neurons with an optical tweezer. Trans Biomed Eng 56:1184–1188
Oddos S, Dunsby C, Purbhoo MA, Chauveau A, Owen DM, Neil MAA, Davis DM, French PMW (2008) High-speed high-resolution imaging of intercellular immune synapses using optical tweezers. Biophys J 95:66–68
Ashok PC, Dholakia K (2012) Optical trapping for analytical biotechnology. Curr Opin Biotechnol 23:16–21
Blesener T, Mondal A, Menon JU, Nguyen KT, Mohanty S (2013) Optical tweezers based measurement of PLGA-NP interaction with prostate cancer cells. Prog Biomed Opt Imaging – Proc SPIE 8594, Article no. 859407
Nakamura H, Karube I (2003) Current research activity in biosensors. Anal Bioanal Chem 377:446–468
Grieshaber D, MacKenzie R, Voros J, Reimhult E (2008) Electrochemical biosensors – sensor principles and architectures. Sensors 8:1400–1458
Velasco-Garcia MN (2009) Optical biosensors for probing at the cellular level: a review of recent progress and future prospects. Sem Cell Dev Biol 20:27–33
Dey D, Goswami T (2011) Optical biosensors: a revolution towards quantum nanoscale electronics device fabrication. J Biomed Biotechnol, Article no. 348218, 7 pages, 2011. doi:10.1155/2011/348218
Tombelli S, Minunni M, Mascini M (2005) Piezoelectric biosensors: strategies for coupling nucleic acids to piezoelectric devices. Methods 37:48–56
Cooper MA (2003) Label-free screening of bio-molecular interactions. Anal Bioanal Chem 377:834–842
Davis JJ, Coleman KS, Azamian BR, Bagshaw CB, Green MLH (2003) Chemical and biochemical sensing with modified single walled carbon nanotubes. Chem Eur J 9:3732–3739
Du D, Chen S, Song D, Li H, Chen X (2008) Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface. Biosens Bioelectron 24:475–479
Deng Z, Zhang Y, Yue J, Tang F, Wei Q (2007) Green and orange CdTe quantum dots as effective pH-sensitive fluorescent probes for dual simultaneous and independent detection of viruses. J Phys Chem 111:12024–12031
Zhang X, Guo Q, Cui D (2009) Recent advances in nanotechnology applied to biosensors. Sensor 9:1033–1053
Li NB, Park JH, Park K, Kwon SJ, Shin H, Kwak J (2008) Characterization and electrocatalytic properties of Prussian blue electrochemically deposited on nano-Au/PAMAM dendrimer-modified gold electrode. Biosens Bioelectron 23:1519–1526
Abbas A, Fei M, Tian L, Singamaneni S (2013) Trapping proteins within gold nanoparticle assemblies: dynamically tunable hot-spots for nanobiosensing. Plasmonics 8:537–544
Dorvel BR, Reddy B, Go J, Duarte Guevara C, Salm E, Alam MA, Bashir R (2012) Silicon nanowires with high-k hafnium oxide dielectrics for sensitive detection of small nucleic acid oligomers. ACS Nano 6:6150–6164
Lakshmi D, Bossi A, Whitcombe MJ, Chianella I, Fowler SA, Subrahmanyam S, Piletska EV, Piletsky SA (2009) Electrochemical sensor for catechol and dopamine based on a catalytic molecularly imprinted polymer-conducting polymer hybrid recognition element. Anal Chem 81:3576–3584
Piletsky SA, et al. (2005) Molecularly imprinted polymers-tyrosinase mimics. Ukrainskii biokhimicheskii zhurnal 77.6:63
Vasapollo G, Del Sole R, Mergola L, Lazzoi MR, Scardino A, Scorrano S, Mele G (2011) Molecularly imprinted polymers: present and future prospective. Int J Mol Sci 12:5908–5945
Berti F, Todrosb S, Lakshmi D, Whitcombec MJ, Chianellac I, Ferronib M, Piletskyc SA, Turnerc APF, Marrazzaa G (2010) Quasi-monodimensional polyaniline nanostructures for enhanced molecularly imprinted polymer-based sensing. Biosens Bioelectron 26:497–503
Akbulut M, Lakshmi D, Whitcombe MJ, Piletska EV, Chianella I, Guven O, Piletsky SA (2011) Microplates with adaptive surfaces. ACS Comb Sci 13:646–652
Ivanova-Mitseva PK, Fragkou V, Lakshmi D, Whitcombe MJ, Davis F, Guerreiro A, Crayston JA, Ivanova DK, Mitsev PA, Piletska EV, Piletsky SA (2011) Conjugated polymers with pendant iniferter units: versatile materials for grafting. Macromolecules 44:1856–1865
Dixit CK, Kaushik A (2012) Nano-structured arrays for multiplex analyses and lab-on-a-chip applications. Biochem Biophys Res Commun 419:316–320
Jain KK (2007) Nanotechnology in medical practice. Med Princ Pract 17:89–101
Shen N, Datta D, Schaffer CB, LeDuc P, Ingber DE, Mazur E (2005) Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mech Chem Biosys 2:17–25
Uchugonova A, Zhang H, Lemke C, König K (2011) Nanosurgery with near-infrared 12-femtosecond and picosecond laser pulses. Prog Biomed Opt Imaging –Proc SPIE 7903, Article no. 79031N
Tserevelakis GJ, Psycharakis S, Resan B, Brunner F, Gavgiotaki E, Weingarten K, Filippidis G (2012) Femtosecond laser nanosurgery of sub-cellular structures in HeLa cells by employing Third Harmonic Generation imaging modality as diagnostic too. J Biophotonics 5:200–220
Beard JD, Gordeev SN, Guy RH (2011) AFM nanotools for surgery of biological cells. J Phys Conf Ser 286, Article no. 012003
Song B, Yang R, Xi N, Patterson KC, Qu C, Lai KWC (2012) Cellular-level surgery using nano robots. J Lab Autom 17:425–434
Boisseau P, Loubaton B (2011) Nanomedicine, nanotechnology in medicine. C R Phys 12:620–636
Murday, James S., et al. (2009) Translational nanomedicine: status assessment and opportunities. Nanomedicine: Nanotechnology, Biology and Medicine 5.3:251–273
Duke T (2003) Hair bundles: nano-mechanosensors in the inner ear. J Phys Condens Matter 15:1747–1757
Alteheld N, Roessler G, Walter P (2007) Towards the bionic eye – the retina implant: surgical, opthalmological and histopathological perspectives. Acta Neurochir Suppl 97:487–493
Keserü M, Feucht M, Bornfeld N, Laube T, Walter P, Rössler G, Velikay-Parel M, Hornig R, Richard G (2012) Acute electrical stimulation of the human retina with an epiretinal electrode array. Acta Ophthalmol 90:1–8
Liu-Snyder P, Webster TJ (2008) Developing a new generation of bone cements with nanotechnology. Curr Nanosci 4:111–118
Khang D, Lu J, Yao C, Haberstroh KM, Webster TJ (2008) The role of nanometer and sub-micron surface features on vascular and bone cell adhesion on titanium. Biomaterials 29:970–983
Wang F, Shi L, He W-X, Han D, Yan Y, Niu Z-Y, Shi S-G (2013) Bioinspired micro/nano fabrication on dental implant-bone interface. Appl Surf Sci 265:480–488
Hersel U, Dahmen C, Kessler H (2003) RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24:4385–4415
Bae YH, Park K (2011) Targeted drug delivery to tumors: myths reality and possibility. J Control Release 153:198–205
Green M, Howman E (2005) Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun 1:121–123
Hankin S, Boraschi D, Dushci A, Lehr CM, Lechtenbeld H (2011) Towards nanotechnology regulation – publish the unpublishable. Nanotoday 6:228–231
Krug HF, Wick P (2011) Nanotoxicology: an interdisciplinary challenge. Angew Chem Int Ed 50:1260–1278
Savolainen K, Aleniusa H, Norppa H, Pylkkänen L, Tuomi T, Kasper G (2010) Risk assessment of engineered nanomaterials and nanotechnologies – a review. Toxicology 269:92–104
Nel A, Xi T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627
Seaton A, Tran L, Aitken R, Donaldson K (2010) Nanoparticles human health hazard and regulation. J R Soc Interface 7:119–129
Howard J (2011) Dynamic oversight: implementation gaps and challenges. J Nanopart Res 13:1427–1434
Bellan LM, Wu D, Langer RS (2011) Current trends in nanobiosensor technology. Nanomed Nanobiotechnol 3:229–246
Wedmid A, Llukani E, Lee DI (2011) Future perspectives in robotic surgery. BJU Int 108:1028–1103
Cooper, Matthew A, Victoria T. Singleton (2007) A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions”. Journal of Molecular Recognition 20.3:154–184
Caldorera-Moore, Mary, Nicholas A. Peppas (2009) Micro-and nanotechnologies for intelligent and responsive biomaterial-based medical systems. Advanced drug delivery reviews 61.15:1391–1401
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Habib-Ullah, S., Fei, D., Ge, Y. (2014). Nanotechnology in Advanced Medical Devices. In: Ge, Y., Li, S., Wang, S., Moore, R. (eds) Nanomedicine. Nanostructure Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2140-5_8
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