Nanomedicine pp 117-143 | Cite as

Medical Nanobiosensors

Chapter
Part of the Nanostructure Science and Technology book series (NST)

Abstract

Diagnostic technology is a vital field for the progress of healthcare and medicine. The most conventional techniques of diagnostic technologies (such as ELISA and PCR) report different handicaps including high cost and time consuming labors. In this regard, novel advances in diagnostic technology are highly desired. Biosensors are useful devices that enable the detection of molecules with diagnostic interest. Since nanotechnology enables the manipulation and control at the nanoscale, biosensors based on nanotechnology or nanobiosensors offer powerful capabilities to diagnostic technology. Here we describe the basic principles of the nanobiosensors and discuss different nanobiosensing strategies towards medical applications focused on three categories: neurodegenerative diseases, cardiovascular diseases and cancer.

Keywords

Nanobiosensor Biomarker Nanomaterials Neurodegenerative diseases Cardiovascular diseases Cancer 

Abbreviations

Abs

Antibodies

AD

Alzheimer’s disease

AuNPs

Gold nanoparticles

CA125

Cancer antigen 125

CA15-3

Cancer antigen 15-3

CEA

Carcionoembryonic antigen

CJD

Creutzfeldt-Jakob disease

CNTs

Carbon nanotubes

cTnT

Cardiac troponin-T

EGFR

Epidermal growth factor receptor

ELISA

Enzyme linked immunosorbent assay

FRET

Fluorescence resonance energy transfer

HER2

Human epidermal growth factor receptor 2

HRP

Horseradish peroxidase

IUPAC

International Union of Pure and Applied Chemistry

MMP-9

Matrix metalloproteinase 9

MNPs

Magnetic nanoparticles

MWCNTs

Multi-walled carbon nanotubes

oxLDL

Oxidized low density lipoprotein

PCR

Polymerase chain reaction

PD

Parkinson’s disease

PrP

Prion proteins

PSA

Prostate specific antigen

QDs

Quantum dots

SWCNT

Single-walled carbon nanotubes

Notes

Acknowledgements

We acknowledge funding from the fellowship program grant given by CONACYT (Mexico) to Eden Morales-Narváez. MCINN (Madrid) through project MAT2011-25870 and E.U. through FP7 “NADINE” project (contract number 246513) have sponsored this work.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Nanobioelectronics & Biosensors GroupCatalan Institute of Nanoscience and NanotechnologyBarcelonaSpain
  2. 2.ESAII DepartmentPolytechnic University of CataloniaBarcelonaSpain
  3. 3.ICREABarcelonaSpain

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