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Nanorobotics pp 425-455 | Cite as

Protein-Based Nanoscale Actuation

  • Gaurav Sharma
  • Atul Dubey
  • Constantinos Mavroidis
Chapter

Abstract

This chapter discusses protein-based nanoscale actuation mechanisms with two illustrative examples, the viral protein linear nanoActuator and the GCN4 peptide nanoActuator. The VPL peptide is based on the conformation change mechanism of envelope glycoprotein of naturally occurring retroviruses. The GCN4 is an artificial design based on two α-helical coils. Structural features, stability, and optimal design considerations are described in detail. Computational methods are applied to gain knowledge about a given molecule and its suitability to function as a nanoActuator.

Keywords

Protein Data Bank Root Mean Square Deviation Coiled Coil Fusion Peptide Steer Molecular Dynamic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Gaurav Sharma
    • 1
  • Atul Dubey
    • 2
  • Constantinos Mavroidis
    • 3
  1. 1.Battelle Memorial InstituteColumbusUSA
  2. 2.Department of Chemical and Biochemical EngineeringRutgers UniversityPiscatawayUSA
  3. 3.Department of Mechanical and Industrial EngineeringNortheastern UniversityBostonUSA

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