Cell and Tissue Therapy in Regenerative Medicine

  • Ana Sánchez
  • Thomas Schimmang
  • Javier García-SanchoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 741)


Cell therapy is one of the most promising future techniques in the medical arsenal for the repair of damaged or destroyed tissue. The diseases which cell therapy can target are very varied: Hormonal dysfunction, such as diabetes and growth hormone deficiency; neurodegenerative diseases, such as Parkinson’s, Alzheimer’s and Huntington’s; and cardiovascular lesions, such as myocardial infarction, peripheral vascular ischaemia; as well as lesions in the cornea, skeletal muscle, skin, joints and bones etc. The objective of cell therapy is to restore the lost function rather than produce a new organ, which could cause duplicity and undesirable effects. Several resources of cells can be used to restore the damaged tissue, such as resident stem cells, multipotent adult progenitor cells or embryonic stem cells. Some cell therapies have been established and approved for clinical use, such as artificial skin derived from keratinocytes, derived from chondrocyte, cells of the corneal limbus or pancreatic islet transplantation. These therapies have had good results, although the scarcity of the starting material may represent a serious limitation. Other therapies under research, using pluripotent stem cells, have been modest so it is useful to review the protocols and try to improve the outcomes. In this chapter we will review the new advances made in this way.


Stem Cell Embryonic Stem Cell Bone Marrow Cell Cell Therapy Pluripotent Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Ana Sánchez
    • 1
  • Thomas Schimmang
    • 1
  • Javier García-Sancho
    • 1
    Email author
  1. 1.Instituto de Biología y Genética Molecular (IBGM)University of Valladolid and Spanish Research Council (CSIC)ValladolidSpain

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