Tissue Bioengineering and Artificial Organs

  • Sara Llames
  • Eva García
  • Jesús Otero Hernández
  • Álvaro MeanaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 741)


The scarcity of organs and tissues for transplant and the need of immunosuppressive drugs to avoid rejection constitute two reasons that justify organ and tissue production in the laboratory. Tissue engineering based tissues (TE) could allow to regenerate the whole organ from a fragment or even to produce several organs from an organ donor for grafting purposes. TE is based in: (1) the ex vivo expansion of cells, (2) the seeding of these expanded cells in tridimensional structures that mimic physiological conditions and, (3) grafting the prototype. In order to graft big structures it is necessary that the organ or tissue produced “ex vivo” bears a vascular tree to ensure the nutrition of its deep layers. At present, no technology has been developed to provide this vascular tree to TE derived products. Thus, these tissues must be thin enough to acquire nutrients during the first days by diffusion from surrounding tissues. This fact constitutes nowadays the greatest limitation of technologies for organ development in the laboratory.

In this chapter, all these problems and their possible solutions are commented. Also, the present status of TE techniques in the regeneration of different organ systems is reviewed.


Tissue Engineering Stem Cell Transplantation Acute Liver Failure Tissue Engineer Vascular Tree 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Sara Llames
    • 1
  • Eva García
    • 1
  • Jesús Otero Hernández
    • 2
  • Álvaro Meana
    • 1
    Email author
  1. 1.Tissue Engineering Unit, Community Centre for Blood and Tissues of AsturiasBiomedical Network Research Centre on Rare DiseasesOviedoSpain
  2. 2.Transplant Coordination UnitHospital Universitario Central de AsturiasOviedoSpain

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