Therapeutic Cloning and Cellular Reprogramming

  • Ramon M. Rodriguez
  • Pablo J. Ross
  • Jose B. CibelliEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 741)


Embryonic stem cells are capable of differentiating into any cell-type present in an adult organism, and constitute a renewable source of tissue for regenerative therapies. The transplant of allogenic stem cells is challenging due to the risk of immune rejection. Nevertheless, somatic cell reprogramming techniques allow the generation of isogenic embryonic stem cells, genetically identical to the patient. In this chapter we will discuss the cellular reprogramming techniques in the context of regenerative therapy and the biological and technical barriers that they will need to overcome before clinical use.


Embryonic Stem Cell Pluripotent Stem Cell Human Embryonic Stem Cell Gene Expression Programme Nuclear Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Ramon M. Rodriguez
    • 1
  • Pablo J. Ross
    • 2
  • Jose B. Cibelli
    • 3
    • 4
    • 5
    Email author
  1. 1.Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCAUniversidad de OviedoOviedoSpain
  2. 2.Department of Animal ScienceUniversity of California-DavisDavisUSA
  3. 3.Cellular Reprogramming Laboratory, Department of Animal ScienceMichigan State UniversityEast LansingUSA
  4. 4.Department of PhysiologyMichigan State UniversityEast LansingUSA
  5. 5.Andalusian Cell Therapy and Regenerative Medicine ProgrammeAndalusiaSpain

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