Principles and Safety of Radiofrequency and Cryo Ablation

  • Pascal R. Fuchshuber


Radiofrequency ablation (RFA) is a particular form of radiofrequency electrosurgery that takes advantage of the ability of radiofrequency alternating current to create heat in biologic tissue. RFA is used for the destruction of unwanted tissue in many medical specialties including cardiology, urology, thoracic surgery, and oncologic surgery. The ability of radiofrequency current to ablate tissue is variable and greatly depends on the tissue to be ablated and the properties of the tissue in which the target lesion is embedded. Several safety issues need to be considered including potential injuries to the operator and patient as well as safety concerns with regard to the effectiveness of RFA. Many different proprietary systems are currently available, and it is important that the user of a particular system is very familiar with its particular properties, use, and application algorithms.


Target Tissue Target Lesion Active Electrode Ablation Zone Thermal Coagulation 
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  1. 1.
    Rhim H, Dodd 3rd GD. Radiofrequency thermal ablation of liver tumors. J Clin Ultrasound. 1999;27:221–9.PubMedCrossRefGoogle Scholar
  2. 2.
    Siperstein AE, Gitomirski A. History and technological aspects of radiofrequency thermoablation. Cancer J. 2000;6 Suppl 4:5293–303.Google Scholar
  3. 3.
    Pereira PL, Trybenbach J, Schenk M, Subke J, et al. Radiofrequency ablation: in vivo comparison of four commercially available devices in pig livers. Radiology. 2004;232:482–90.PubMedCrossRefGoogle Scholar
  4. 4.
    Chang CK, Handy MP, Smith JM, Recht MH, Welling RE. Radiofrequency ablation of the porcine liver with complete hepatic vascular occlusion. Ann Surg Oncol. 2002;9:594–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Livraghi T, Solbiati L, Meloni F, Gazelle S, Halpern EF, Goldberg SN. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multitcenter study. Radiology. 2003;226:441–51.PubMedCrossRefGoogle Scholar
  6. 6.
    Curley SA, Rizzo F, Ellis LM, Vaughan JN, Val lone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg. 2000;232:381–91.PubMedCrossRefGoogle Scholar
  7. 7.
    Kuvshinoff BW, Ota DM. Radiofrequency ablation of liver tumors: influence of technique and tumor size. Surgery. 2002;132:605–11.PubMedCrossRefGoogle Scholar
  8. 8.
    Aloia TA, Vauthey JN, Loyer EM, Ribero D, Pawlik TM, Wei SH, Curley SA, Zorzi D, Abdalla EK. Solitary colorectal liver metastasis: resection determines outcome. Arch Surg. 2006;141(5):460–6; discussion 466–7.Google Scholar
  9. 9.
    Pawlik TM, Izzo F, Cohen DS, Morris JS, Curley SA. Combined resection and radiofrequency ablation for advanced hepatic malignancies: results in 172 patients. Ann Surg Oncol. 2003;10:1059–69.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Pascal R. Fuchshuber
    • 1
  1. 1.Hepatobiliary and Oncologic Surgery, The Permanente Medical Group, Inc.Walnut CreekUSA

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