A Practitioner’s Guide to Prescribing Topiramate for Adults with Intellectual Disabilities

  • Jose de Leon


We developed this topiramate guideline using drug prescribing information and reviewing the available literature on relevant neuropsychiatric disorders in populations without intellectual disabilities because of the dearth of available literature on the population with intellectual disabilities. This guideline includes indications, contraindications, assessments prior to and during treatment, dosing with particular focus on dosing modifications required by drug–drug interactions or personal characteristics, and adverse drug reactions. The procedures contained in this guideline may not fully account for all of the possible risks of treatment in this population because of the limited studies available; thus, there will be a need to periodically update this guideline as new information becomes available. Nevertheless, we believe that this guideline provides a useful resource for clinicians who treat epilepsy in adult ­individuals with intellectual disabilities. A topiramate drug utilization review that summarizes this guideline is described.


Eating Disorder Intellectual Disability Therapeutic Drug Monitoring Carbonic Anhydrase Inhibitor Slow Titration 
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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jose de Leon
    • 1
  1. 1.Department of Psychiatry College of MedicineUniversity of KentuckyLexingtonUSA

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