Abstract
Breast cancer is increasing 3.1 % annually. It is more deadly and more frequent in young women in developing countries compared to young women in the more developed countries. Important reasons for this increased incidence and lethality are poor nutrition (leading to decreased immunity to resist the advance of cancer), delayed access to health care, and poor quality of care when it is finally available. Early detection of breast cancer is the key to the control of its lethal effects. Increasing breast health awareness and clinical breast examination are key components of a screening program at the present time. Such a strategy is aimed at detecting Stage I and Stage II cancers and downstaging cancers from the now prevalent presentation at Stage III and Stage IV. For the future, however, a low cost methodology needs to be adopted in order to diagnose small node-negative cancers by screening the asymptomatic population. Organized screening mammography is not a feasible option for low and mid-resource countries, even in the future. A combination of low prevalence and the expensive infrastructure needed in terms of the equipment and trained health-care professionals makes this an unrealistic option and a potential drain and diversion of health-care funding resources in developing countries. The background of the situation that is currently in existence, problems thereof, and the potential for the use of whole breast ultrasound screening for breast cancer is discussed in this chapter.
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References
Forouzanfar MH, Foreman KJ, Delossantos AM, Lozao R, Lopez AD, Murray CJ, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet. 2011;378(9801):1461–84.
Pavelic L, Pavelic K, Vuk-Pavelic S. Human mammary and bronchial carcinomas in vivo and in vitro secretion of substances immunologically cross-reactive with insulin. Cancer. 1984;53:2467–71.
Ziegler RG, Anderson WF, Gail MH. Increasing breast cancer incidence in China: the numbers add up. JNCI. 2008;100:1339–41.
Polyak K. Breast cancer: origins and evolution. J Clin Invest. 2007;117:3155–63.
Satyaraj E. Emerging paradigms in immunonutrition. Top Companion Anim Med. 2011;26(1):25–32.
Farmer H, McCabe N, Lord C, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434:917–21.
Bittner JJ. Some possible effects of nursing on the mammary gland tumor incidence in mice. Science. 1936;84:162.
Ross SR. Mouse mammary tumor virus molecular biology and oncogenesis. Viruses. 2010;2:2000–12.
Akil N, Yasmeen A, Kassab A, Ghabreau L, Darnel AD, Moustafa A-E. High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study. Br J Cancer. 2008;99:404–7.
Kroupis C, Markou A, Vourlidis N, Dionyssiou-Asteriou A, Lianidou ES. Presence of high-risk human papillomavirus sequences in breast cancer tissues and association with histopathological characteristics. Clin Biochem. 2006;39:727–31.
Hariri S, Unger ER, Sternberg M, Dunne EF, Swan D, Patel S, et al. Prevalence of genital HPV in the among females in the United States, the National Health and Nutrition Examination Survey, 2003–2006. J Infect Dis. 2011;204(4):566–73.
Shenefelt PD. Nongenital warts. Medscape Reference Drugs Disease & Procedures. 2012. http://emedicine.medscape.com/article/1133317-overview
Khan S, Jaffer NN, Khan MN, Rai MA, Shafiq M, Ali A, et al. Human papillomavirus subtype 16 is common in Pakistani women with cervical carcinoma. Int J Infect Dis. 2007;11(4):313–7.
Center for Communicable Diseases. Epidemiology and prevention of vaccine-preventable diseases: human papillomavirus. The pink book: course textbook, Ch 10, 12th ed. Washington, DC: Public Health Foundation; 2012. p. 139–49.
Clifford GM, Smith JS, Aguado T, Franceschi S. Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. Br J Cancer. 2003;89:101–5.
Barth AJ Jr, Gibson GR, Mott LA, Becher RD, Poplack SP. Detection of breast cancer on screening mammography allows patients to be treated with less-toxic therapy. AJR. 2005;184:325–9.
Nelson HD, Tyne K, Naik A, Bougatsos C, Chan BK, Humphrey L. Screening for breast cancer: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 2009;151:727–37.
Duffy SW, Tabár L, Vitak B, Warwick J. Tumor Size and breast cancer detection: what might be the effect of a less sensitive screening tool than mammography? Breast J. 2006; 12 Suppl 1:S91–5.
Yu Y-H, Wei W, Liu J-L. Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis. BMC Cancer. 2012;12:41.
Ljung BM, Drejet A, Chiampi N, Jeffrey J, Goodson WH 3rd, Chew K, et al. Diagnostic accuracy of fine-needle aspiration biopsy is determined by physician training in sampling technique. Cancer. 2011;93(4):263–8.
Tabár L, Vitak B, Chen TH, Yen AM, Cohen A, Tot T, et al. Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades. Radiology. 2011;260:658–63.
Keen C. SSPs take on larger role in digital mammography. Hefty data sets and multiple prior images threaten to put a strain on standard storage and network options. Diagnostic Imaging. 2005;27:S-23–31. http://www.diagnosticimaging.com/display/article/113619/1197582. Cited 17 Aug 2012.
Kelly KM, Dean J, Comulada WS, Lee S-J. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts. Eur Radiol. 2010;20:734–42.
Elmore JG, Armstrong K, Lehman CD, et al. Screening for breast cancer. JAMA. 2005;293:1245–56.
Nothacker M, Duda V, Hahn M, et al. Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue: a systematic review. BMC Cancer. 2009;9:1–9.
Berg WA, Blume JD, Cormack JB, et al. Combined screening with ultrasound and mammography vs. mammography alone in women with elevated risk of breast cancer. JAMA. 2008;299:2151–63.
Tohno E, Ueno E, Watanabe H. Ultrasound screening of breast cancer. Breast Cancer. 2009;16:18–22.
Kuhl CK. The “coming of age” of nonmammographic screening for breast cancer. JAMA. 2008;299:2203–5.
Tohno E, Takahashi H, Tamada T, Fujimoto Y, Yasuda H, Ohuchi N. Educational program and testing using images for the standardization of breast cancer screening by ultrasonography. Breast Cancer. 2012;19(2):138–46.
Kelly KM, Richwald GA. Automated whole-breast ultrasound: advancing the performance of breast cancer screening. Semin Ultrasound CT MRI. 2011;32:273–80.
Tabár L. Personal Communication. Santa Barbara, California. Summer 2011.
WHO International Agency for Research on Cancer. Breast cancer incidence and mortality worldwide in 2008 summary. 2008. http://globocan.iarc.fr/factsheets/cancers/breast.asp. Cited 17 Aug 2012.
References
Saslow D, Castle PE, Cox JT, Davey DD, Einstein MH, Ferris DG, et al. American Cancer Society Guideline for human papillomavirus (HPV) vaccine use to prevent cervical cancer and its precursors. CA Cancer J Clin. 2007;57(1):7–28.
Burchell AN, Winer RL, de Sanjose S, Franco EL. Chapter 6: Epidemiology and transmission dynamics of genital HPV infection. Vaccine. 2006;24 Suppl 3:S3/52–61.
WHO. Initiative for vaccine research (IVR)—viral cancer—HPV. World Health Organization. 2011. http://www.who.int/vaccine_research/diseases/viral_cancers/en/index3.html. Cited 30 Jun 2012.
Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2(9):533–43.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon: International Agency for Research on Cancer; 2011. http://globocan.iarc.fr. Cited 30 Jun 2012.
Update on Human Papillomavirus (HPV) Vaccines. CCDR (Canada communicable disease report) 2012;38:1–62.
WHO. Human papillomavirus and HPV vaccines: technical information for policy-makers and health professionals. Geneva: WHO Press; 2007. p. 43.
WHO/ICO. Human papillomavirus and related cancers in world. Summary report update. October 9, 2009. WHO/ICO Information Centre on HPV and Cervical Cancer. 2009.
Parkin DM, Bray F. Chapter 2: The burden of HPV-related cancers. Vaccine. 2006;24 Suppl 3:S3/11–25.
WHO. Human papillomavirus vaccines. WHO position paper. Weekly Epidemiological Record 2009;15:118–31.
Brotherton JM, Fridman M, May CL, Chappell G, Saville AM, Gertig DM. Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study. Lancet. 2011;377(9783):2085–92.
Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Unger ER. Quadrivalent human papillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007;56(RR-2):1–24.
FDA. Vaccines, blood & biologics. Vaccines. Approved products FDA; 2012. http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm172678.htm. Cited 2012 Jul 20, 2012.
Garland SM, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med. 2007;356(19):1928–43.
Villa LL, Costa RL, Petta CA, Andrade RP, Paavonen J, Iversen OE, et al. High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up. Br J Cancer. 2006;95(11):1459–66.
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N Engl J Med. 2007;356(19):1915–27.
Paavonen J, Naud P, Salmeron J, Wheeler CM, Chow SN, Apter D, et al. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet. 2009;374(9686):301–14.
Lehtinen M, Paavonen J, Wheeler CM, Jaisamrarn U, Garland SM, Castellsague X, et al. Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial. Lancet Oncol. 2012;13(1):89–99.
Villa LL. HPV prophylactic vaccination: the first years and what to expect from now. Cancer Lett. 2011;305(2):106–12.
Villa LL, Costa RL, Petta CA, Andrade RP, Ault KA, Giuliano AR, et al. Prophylactic adrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol. 2005;6(5):271–8.
Stokley S, Cohn A, Dorell C, Hariri S, Yankey D, Messonnier N, et al. Adolescent vaccination-coverage levels in the United States: 2006–2009. Pediatrics. 2011;128(6):1078–86.
Finn A. Strategy options for HPV vaccine delivery in EU countries. Guidance for the introduction of HPV vaccines in EU countries. Stockholm: European Centre for Disease Prevention and Control; 2008. p. 30–6.
Garland SM, Skinner SR, Brotherton JM. Adolescent and young adult HPV vaccination in Australia: achievements and challenges. Prev Med. 2011;53 Suppl 1:S29–35.
Immunise Australia Program. Human Papillomavirus (HPV). Information about the National Human Papillomavirus (HPV) Vaccination Program funded under the Immunise Australia Program.: Australian Government. Depatment of Health and Aging; 2011 [updated Apr 04, 2011]; http://www.immunise.health.gov.au/internet/immunise/publishing.nsf/Content/immunise-hpv#figure2. Cited 30 Jun 2012.
Dorleans F, Giambi C, Dematte L, Cotter S, Stefanoff P, Mereckiene J, et al. The current state of introduction of human papillomavirus vaccination into national immunisation schedules in Europe: first results of the VENICE2 2010 survey. Euro surveillance: bulletin europeen sur les maladies transmissibles = European communicable disease bulletin 2010;15(47).
HPV Vaccine: Implementation and Financing Policy. The Henry J. Kaiser Family Foundation. 2007. http://www.kff.org/womenshealth/upload/7602.pdf. Cited 2012.
The HPV Vaccine: Access and Use in the U.S.: The Henry J. Kaiser Family Foundation. 2011. http://www.kff.org/womenshealth/7602.cfm. Cited 2012.
IARC. Making cervical cancer vaccines widely available in developing countries: cost and financing issues. IARC. http://screening.iarc.fr/doc/IAVI_PATH_HPV_financing_brief.pdf. Cited 2012.
Smith LM, Brassard P, Kwong JC, Deeks SL, Ellis AK, Levesque LE. Factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an Ontario cohort of grade 8 girls. BMC Public Health. 2011;11:645.
Colucci R, Hryniuk W, Savage C. HPV vaccination programs in Canada: Are we hitting the mark? Report Card on Cancer in Canada [Internet]. 2010 Aug 11, 2012. Available from: http://www.canceradvocacy.ca/reportcard/2008/HPV%20Vaccination%20Programs%20in%20Canada.pdf.
Progress toward implementation of human papillomavirus vaccination--the Americas, 2006–2010. MMWR Morbidity and mortality weekly report 2011;60(40):1382–4.
LaMontagne DS, Barge S, Le NT, Mugisha E, Penny ME, Gandhi S, et al. Human papillomavirus vaccine delivery strategies that achieved high coverage in low- and middle-income countries. Bull World Health Organ. 2011;89(11):821–30B.
Saxenian H. HPV Vaccine Adoption in Developing Countries: Cost and Financing Issues: International AIDS Vaccine Initiative/Program for Appropriate Technology in Health (PATH). http://www.iavi.org/HPVreport. Cited 2007.
Garland SM. Human papillomavirus vaccination: where to now? Sex Transm Infect. 2011;87 Suppl 2:ii23–4.
GAVI Alliance. http://www.gavialliance.org/. Cited 2012.
GAVI. Human papillomavirus vaccine support. GAVI Alliance. http://www.gavialliance.org/support/nvs/human-papillomavirus-vaccine-support/. Cited 2012.
PAHO. PAHO Revolving Fund. Pan American Health Organization; Available from: http://new.paho.org/hq/index.php?option=com_content&task=view&id=1864&Itemid=2234&lang=en.
Bonanni P, Levi M, Latham NB, Bechini A, Tiscione E, Lai P, et al. An overview on the implementation of HPV vaccination in Europe. Hum Vaccin. 2011;7(Suppl):128–35.
Ladner J, Besson MH, Hampshire R, Tapert L, Chirenje M, Saba J. Assessment of eight HPV vaccination programs implemented in lowest income countries. BMC Public Health. 2012;12:370.
GAP. Gardasil Access Program. 2012. http://www.gardasilaccessprogram.org/section/141. Cited 4 Nov 2012.
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Kelly, K.M., Shetty, M.K., Fregnani, J.H.T.G. (2013). Breast Cancer Screening and Cervical Cancer Prevention in Developing Countries: Strategies for the Future. In: Shetty, M. (eds) Breast and Gynecological Cancers. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1876-4_16
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