For better or for worse, the United States and Mexico are closely connected geographically, economically, politically, culturally and by the interconnectedness of their people. Mexico is a leading trading partner of the United States, and the two nations are highly dependent on each other for economic survival in an increasingly competitive global market. For this and other reasons, the health of both nations is essential in ensuring continued prosperity and growth. For the past century, the United States has led the world in economic might. With that economic and technological success, as in Western Europe, came better public health and increased longevity of its people. Middle-income nations, like Mexico, saw similar trends, but lagged behind their more wealthy counterparts. After the first decade of the twenty-first century, many middle-income nations, including Mexico, appear to be catching up with the United States. With current Mexican gross domestic product growth rates several times that of many of the United States, we may be witnessing not so much the decline of the United States, but as Fareed Zakaria described the “rise of the rest.” This “rise” is not limited to economic growth, but also increases in the proportion of older adults in middle-income nations, including Mexico.