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Cerebral Glucose Transport and Homeostasis

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Neural Metabolism In Vivo

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 4))

Abstract

Cerebral glucose homeostasis is maintained by the equilibrium between glucose transport across the blood-brain-barrier (BBB), which occurs through facilitative carriers, and glucose consumption mainly initiated by hexokinase phosphorylation. Glucose concentrations can be quantified non invasively by nuclear magnetic resonance (NMR) spectroscopy and such measurements, through appropriate mathematical modelling, allow to determine the kinetics of glucose transport and metabolism. This chapter summarizes the insights gained into brain glucose transport from the measurement of the brain glucose concentration, particularly reviewing state of the art NMR methods for non invasive determination of glucose homeostasis and discussing the employment of mathematical models of glucose transport.

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Authors and Affiliations

  1. Laboratory for functional and metabolic imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland

    João M. N. Duarte Ph.D.

  2. Laboratory for functional and metabolic imaging, Ecole Polytechnique Federale de Lausanne, Department of Radiology, University of Lausanne and Geneva, Station 6, CH-1015, Lausanne, Switzerland

    Rolf Gruetter Ph.D.

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  1. João M. N. Duarte Ph.D.
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Correspondence to João M. N. Duarte Ph.D. .

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Editors and Affiliations

  1. School of Medicine, Hoglund Brain Imaging Center, University of Kansas, Rainbow Blvd. 3901, Kansas City, 66160, Kansas, USA

    In-Young Choi

  2. Inst. Physique de la Matière Complexe, Labo. d'Imagerie Fonctionnelle et, Ecole Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland

    Rolf Gruetter

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Duarte, J.M.N., Gruetter, R. (2012). Cerebral Glucose Transport and Homeostasis. In: Choi, IY., Gruetter, R. (eds) Neural Metabolism In Vivo. Advances in Neurobiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1788-0_20

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