Cerebrospinal Fluid

Part of the Essentials in Cytopathology book series (EICP, volume 11)


The lumbar puncture (spinal tap) was introduced in 1891, and in 1904 a French neurologist first described malignant cells in cerebrospinal fluid (CSF). Since then, preparatory methods have been refined and diagnostic features described in a number of monographs and atlases, attesting to the importance of CSF cytology for excluding leptomeningeal metastasis in a patient with neurologic symptoms.


Lymphoma Leukemia Adenoma Meningioma Hydrocephalus 

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© Springer Science + Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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