Cerebrospinal Fluid

  • Syed Z. AliEmail author
  • Edmund S. Cibas
Part of the Essentials in Cytopathology book series (EICP, volume 11)


The lumbar puncture (spinal tap) was introduced in 1891, and in 1904 a French neurologist first described malignant cells in cerebrospinal fluid (CSF). Since then, preparatory methods have been refined and diagnostic features described in a number of monographs and atlases, attesting to the importance of CSF cytology for excluding leptomeningeal metastasis in a patient with neurologic symptoms.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Lyme Disease Small Cell Carcinoma Aseptic Meningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science + Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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