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Metabolomics Applications in Human Nutrition

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Genetics Meets Metabolomics

Abstract

Human metabolism is a continuum. It shifts constantly between anabolic conditions after food intake and catabolic states between meals or during extended starvation periods. At all times there is need of a constant supply of nutrients and metabolites for ATP production and of building blocks for the continuous remodeling of cellular structures. However, the sources of fuels used to maintain metabolic functions are variable (carbohydrates versus lipids versus proteins) depending on frequency of eating and fasting and the quantity and quality of food intake. The profile of the metabolites in any biological sample obtained, taken at any time is a snapshot of an ever-changing “integrated metabolome”. Human plasma, urine or breath metabolomes contain not only endogenously produced metabolites but also the nutrients and metabolites provided by the diet and, in addition, metabolites derived from the microbiota hosted in the human large intestine which are partly absorbed and appear later in blood and urine (Fig. 9.1).

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Authors and Affiliations

  1. Molecular Nutrition Unit, TUM, Gregor-Mendel Str. 2, Freising, 85354, Germany

    Hannelore Daniel & Manuela Sailer M.Sc.

Authors
  1. Hannelore Daniel
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  2. Manuela Sailer M.Sc.
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Correspondence to Hannelore Daniel .

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Editors and Affiliations

  1. Qatar Foundation-Education City, Weill Cornell Medical College in Qatar, Education City – Qatar Foundation, Doha, 24144, Qatar

    Karsten Suhre

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Daniel, H., Sailer, M. (2012). Metabolomics Applications in Human Nutrition. In: Suhre, K. (eds) Genetics Meets Metabolomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1689-0_9

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