Pre-conditions for High Quality Biobanking in Large Human Epidemiological Cohorts for Metabolomics and Other – Omics Studies

Chapter

Abstract

A first generation of large-scale prospective cohorts that included biobanks with blood and/or urine samples was initiated in the late 1980s and early 1990s, in the USA and Europe. Currently, prospective biobank studies of a similar size, including 300,000–500,000 subjects, have started in the UK “as reported by Elliott and Peakman (J Epidemiol 37(2):234–244, 2008),” Sweden, Japan, Western Australia, the USA and Germany. A key element of biobanks is the collection of high quality samples from all study participants. For blood and additional materials high quality preservation of quality relies on minimizing pre-analytical artefacts that may be incurred during specimen collection, primary processing, transport and/or storage of the samples. This is a pre-requisite for later application of systematic molecular analyses like genomics, epigenomics or metabolomics.

Keywords

Europe EDTA Transportation Enzymatic Degradation Catecholamine 

References

  1. 1.
    Elliott P, Peakman TC (2008) The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. J Epidemiol 37(2):234–244CrossRefGoogle Scholar
  2. 2.
    Burton PR, Tobin MD, Hopper JL (2005) Key concepts in genetic epidemiology. Lancet 366(9489):941–951PubMedCrossRefGoogle Scholar
  3. 3.
    Wichmann HE, Gieger C (2007) Biobanks. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50(2):192–199PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Research Unit of Molecular EpidemiologyNeuherbergGermany
  2. 2.Hannover Unified BiobankHannover Medical SchoolHannoverGermany

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