Pre-conditions for High Quality Biobanking in Large Human Epidemiological Cohorts for Metabolomics and Other – Omics Studies

  • Thomas Illig


A first generation of large-scale prospective cohorts that included biobanks with blood and/or urine samples was initiated in the late 1980s and early 1990s, in the USA and Europe. Currently, prospective biobank studies of a similar size, including 300,000–500,000 subjects, have started in the UK “as reported by Elliott and Peakman (J Epidemiol 37(2):234–244, 2008),” Sweden, Japan, Western Australia, the USA and Germany. A key element of biobanks is the collection of high quality samples from all study participants. For blood and additional materials high quality preservation of quality relies on minimizing pre-analytical artefacts that may be incurred during specimen collection, primary processing, transport and/or storage of the samples. This is a pre-requisite for later application of systematic molecular analyses like genomics, epigenomics or metabolomics.


Storage Facility European Prospective Investigation Into Cancer European Prospective Investigation Standard Operation Procedure High Quality Sample 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Research Unit of Molecular EpidemiologyNeuherbergGermany
  2. 2.Hannover Unified BiobankHannover Medical SchoolHannoverGermany

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