Memories of the Moore Clinic, 1960–1965

Chapter

Abstract

Beginning in the 1950s, Victor McKusick established the Moore Clinic as the leading international centre for the development of the new specialty of clinical genetics. Many of those who worked with him at this time were to become leaders in this field, both in the USA and in many other countries. Because McKusick remained firmly embedded in general internal medicine, he was able to bring a wide variety of different fields of research into the development of this new specialty. This short appreciation to the work of McKusick is based on reminiscences of the activities of the Moore Clinic in the early 1960s.

Keywords

Starch Electrophoresis Pier Tray Hydroxyurea 

References

  1. 1.
    Bearn AG (1993) Archibald Garrod and the individuality of man. Clarendon, OxfordGoogle Scholar
  2. 2.
    Garrod AE (1909) Inborn errors of metabolism. In: Royal College of Physicians of London (ed) The Croonian lecture delivered before the Royal College of Physicians of London in June 1908. Frowde/Hodder and Stoughton, LondonGoogle Scholar
  3. 3.
    Garrod AE (1931) The inborn factors of disease. Oxford University Press, OxfordGoogle Scholar
  4. 4.
    McKusick VA (1956) Heritable disorders of connective tissue. Mosby, St. LouisGoogle Scholar
  5. 5.
    Weatherall DJ (1990) Presentation of the George M. Kober Medal to Victor A. McKusick. Trans Assoc Am Physicians 103:cxxii–cxlPubMedGoogle Scholar
  6. 6.
    McKusick VA (1966) Mendelian inheritance in man: catalogs of autosomal dominant, autosomal recessive and X-linked phenotypes. Johns Hopkins University Press, BaltimoreGoogle Scholar
  7. 7.
    Weatherall D (2008) McKusick, Victor. In: Encyclopedia of life sciences. Wiley, ChichesterGoogle Scholar
  8. 8.
    McKusick VA (1989) Forty years of medical genetics. JAMA 261:3155–3158PubMedCrossRefGoogle Scholar
  9. 9.
    McKusick VA (2006) A 60-year tale of spots, maps, and genes. Annu Rev Genomics Hum Genet 7:1–27PubMedCrossRefGoogle Scholar
  10. 10.
    Weatherall DJ, Boyer SH (1961) The genetic control of the α chains of human hemoglobins. Trans Assoc Am Physicians 74:89–99PubMedGoogle Scholar
  11. 11.
    Weatherall DJ, Boyer SH (1962) Evidence for the genetic identity of alpha chain determinants in hemoglobins A, A2 and F. Bull Johns Hopkins Hosp 110:8–22PubMedGoogle Scholar
  12. 12.
    Weatherall DJ, Baglioni C (1962) A fetal hemoglobin variant of unusual genetic interest. Blood 20:675–685PubMedGoogle Scholar
  13. 13.
    Weatherall DJ (1963) Abnormal haemoglobins in the neonatal period and their relationship to thalassaemia. Br J Haematol 9:265PubMedCrossRefGoogle Scholar
  14. 14.
    Weatherall DJ, Clegg JB, Naughton MA (1965) Globin synthesis in thalassemia: an in vitro study. Nature 208:1061–1065PubMedCrossRefGoogle Scholar
  15. 15.
    Clegg JB, Weatherall DJ, Na-Nakorn S, Wasi P (1968) Haemoglobin synthesis in β-thalassaemia. Nature 220:664–668PubMedCrossRefGoogle Scholar
  16. 16.
    Weatherall DJ (2010) Thalassaemia. The biography. Oxford University Press, OxfordGoogle Scholar
  17. 17.
    Weatherall DJ, Clegg JB (2001) The thalassaemia syndromes. Blackwell Science, OxfordCrossRefGoogle Scholar
  18. 18.
    Smith EW, Torbert JV (1958) Study of two abnormal hemoglobins with evidence for a new genetic locus for hemoglobin formation. Bull Johns Hopkins Hosp 102:38–45PubMedGoogle Scholar
  19. 19.
    Charache S, Clegg JB, Weatherall DJ (1976) The Negro variety of hereditary persistence of fetal haemoglobin is a mild form of thalassaemia. Brit J Haematol 34:527CrossRefGoogle Scholar
  20. 20.
    Conley CL, Weatherall DJ, Richardson SN, Shepard MK, Charache S (1963) Hereditary persistence of fetal hemoglobin: a study of 79 affected persons in 15 Negro families in Baltimore. Blood 21:261PubMedGoogle Scholar
  21. 21.
    Charache S, Weatherall DJ, Clegg JB (1966) Polycythemia associated with a hemoglobinopathy. J Clin Invest 45:813PubMedCrossRefGoogle Scholar
  22. 22.
    Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, McMahon RP, Bonds DR (1995) Effect of hydroxyurea on the frequency of painful crises in sickle cell ­anemia. N Engl J Med 332:1317PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Weatherall Institute of Molecular Medicine, John Radcliffe HospitalUniversity of OxfordHeadingtonUK

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