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Delayed Gadolinium-Enhanced MRI of Cartilage

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Hip Magnetic Resonance Imaging

Abstract

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [1]. Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent molecular degeneration in cartilage that was grossly intact morphologically [2]. Since then, over 150 reports of dGEMRIC involving in vitro and clinical studies have been published. These reports demonstrate the potential for molecular imaging techniques to illustrate new paradigms in the understanding of cartilage disease. However, along with the expanded applications come questions regarding appropriate protocols, possible sources of measurement and interpretation errors, and insight into directions for future study. This chapter describes the theoretical basis of dGEMRIC, protocols, pitfalls, and opportunities, focusing on the clinical aspects. Further details can be found in several reviews [3–7].

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  1. Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Boston, MA, USA

    Deborah Burstein PhD

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  1. Department of Orthopedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA

    Young-Jo Kim

  2. Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts, USA

    Tallal Charles Mamisch

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Burstein, D. (2014). Delayed Gadolinium-Enhanced MRI of Cartilage. In: Kim, YJ., Mamisch, T. (eds) Hip Magnetic Resonance Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1668-5_3

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