Non-contrast Biochemical Imaging

  • Stephan Domayer
  • Sebastian Apprich
  • Benjamin Schmitt
  • Oliver Bieri
  • Siegfried Trattnig


Much of the difficulty in studying OA and the efficacy of interventions is due to the current limitations in the use of plain radiographs, which are currently deemed the gold standard for noninvasive assessment of clinical OA. Often, changes such as joint space narrowing or formation of osteophytes, which can be detected on radiographs, manifest at late stage [1], when disease modifying therapies including surgery and/or drug treatment may already be ineffective. Sensitive techniques that could detect early OA and reliably monitor its progression would help to identify patients who may benefit from joint preserving interventions, to reduce the number of patients requiring arthroplasty or at least delaying the need of total hip arthroplasty (THA). In addition, the identification of patients who are likely to progress rapidly would be particularly useful when designing clinical trials. Therefore, an early diagnosis of cartilage degeneration and a sensitive, noninvasive diagnostic tool are highly desirable.


Apparent Diffusion Coefficient Diffusion Weight Image Steady State Free Precession Chemical Exchange Saturation Transfer Cartilage Repair Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Stephan Domayer
    • 1
  • Sebastian Apprich
    • 2
  • Benjamin Schmitt
    • 2
  • Oliver Bieri
    • 3
  • Siegfried Trattnig
    • 4
  1. 1.Department of OrthopaedicsMedical University of ViennaViennaAustria
  2. 2.Department of Radiology, Centre for High-Field MRMedical University of ViennaViennaAustria
  3. 3.Division of Radiological Physics, Department of RadiologyUniversity of Basel HospitalBaselSwitzerland
  4. 4.Department of RadiologyMedical University of ViennaViennaAustria

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