Abstract
We designed and synthesized phenolic BODIPY-containing antioxidants as traceable next-generation drug model named boron tracedrugs, UTX-42, UTX-43, and UTX-44. These drugs are basically composed of phenolic antioxidant moiety and stable boron-containing BODIPY moiety. Their antioxidant activities were evaluated by spectroscopic analysis with ABTS radical cations and inhibitory activity on lipid peroxidation of rat liver mitochondria. The reactivity of them with ABTS radical cations showed to be higher than trolox, which is one of the well-known antioxidants. These trace drugs, especially UTX-44, also showed much higher inhibitory activity than trolox against RLM lipid peroxidation. These results demonstrated that UTX-44 had the most potent boron-containing antioxidant among these drugs.
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Acknowledgments
We thank Ms. Maki Nakamura, Ms. Emiko Okayama, and the staff of our faculty for measurement of NMR and elemental analyses. We also thank Prof. Toshihiro Hashimoto and Ms. Yasuko Okamoto for measurement of FAB-MS.
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Nakata, E., Koizumi, M., Yamashita, Y., Uto, Y., Hori, H. (2012). Boron Tracedrug: Design, Synthesis, and Pharmacological Activity of Phenolic BODIPY-Containing Antioxidants as Traceable Next-Generation Drug Model. In: Wolf, M., et al. Oxygen Transport to Tissue XXXIII. Advances in Experimental Medicine and Biology, vol 737. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1566-4_44
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DOI: https://doi.org/10.1007/978-1-4614-1566-4_44
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