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Blood Flow and Oxygenation Status of Gastrointestinal Tumors

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Oxygen Transport to Tissue XXXIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 737))

Abstract

Tumor hypoxia is a major driving force for malignant progression since it can promote local invasion of cancer cells and metastatic spread to distant sites [1–7]. Tumor hypoxia also plays a key role in the development of acquired treatment resistance since it is capable of directly and/or indirectly conferring resistance to therapy [8, 9]. As a result, hypoxia has been shown to act as an independent, adverse prognostic factor [10–14]. Due to this seminal role of tumor hypoxia, knowledge concerning the oxygenation status of malignant tumors in terms of O2 tension distributions and detection of hypoxia are indispensable in the clinical setting. For this reason, the respective oxygenation status for gastrointestinal (GI) malignancies have been compiled in this review, together with blood flow values (where available), which are major determinants of the oxygen status. Pretherapeutic data of the following tumor entities will be presented: Cancers of the stomach, gallbladder, common bile duct, pancreas, colon, rectum, and primary and metastatic liver tumors.

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Acknowledgments

This work has been supported by a grant from the Deutsche Krebshilfe (106758).

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Authors and Affiliations

  1. Tumor Pathophysiology Division, Department of Radiooncology and Radiotherapy, University Medical Center, Langenbeckstrasse 1, 55131, Mainz, Germany

    Peter Vaupel

  2. Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, München, Germany

    Peter Vaupel

  3. Institute of Functional and Clinical Anatomy, University Medical Center, Johannes-Joachim-Becher-Weg 13, 55128, Mainz, Germany

    Debra K. Kelleher

Authors
  1. Peter Vaupel
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  2. Debra K. Kelleher
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Corresponding author

Correspondence to Peter Vaupel .

Editor information

Editors and Affiliations

  1. , Division of Neonatology, University Hospital Zurich, Frauenklinikstr. 10, Zurich, 8091, Switzerland

    Martin Wolf

  2. , Division of Neonatology, University Hospital Zurich, Frauenklinikstr. 10, Zurich, 8091, Switzerland

    Hans Ulrich Bucher

  3. Institute for Biomedical Engineering, University of Zurich/ETHZ, Wolfgang-Pauli-Strasse 27, Zurich, 8093, Switzerland

    Markus Rudin

  4. ESAT-SCD(SISTA), Dept. Elektrotechniek, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee, 3001, Belgium

    Sabine Van Huffel

  5. , Institute of Complementary Medicine KIKO, University of Bern, Imhoof-Pavillon, Inselspital, Bern, 3010, Switzerland

    Ursula Wolf

  6. Synthesizer Inc., Synthesizer Inc. 2773, Ellicott City, 21043, Maryland, USA

    Duane F. Bruley

  7. , Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom

    David K Harrison

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Vaupel, P., Kelleher, D.K. (2012). Blood Flow and Oxygenation Status of Gastrointestinal Tumors. In: Wolf, M., et al. Oxygen Transport to Tissue XXXIII. Advances in Experimental Medicine and Biology, vol 737. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1566-4_20

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