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Cardiovascular Disease in Women

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Coronary Heart Disease

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Abstract

Cardiovascular disease (CVD) is the leading cause of death in women of all age. An understanding of CVD in women is critical, especially given the aging population and the growing incidence of obesity, diabetes, and metabolic syndrome in our society. This chapter covers gender differences in risk factors for CVD, symptom presentation, and disease progression, as well as implications for diagnosis and treatment.

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References

  1. Centers for Disease Control and Prevention. State-specific mortality from sudden cardiac death – United States. Centers for Disease Control and Prevention Web site. 1999. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5106a3.html. Published Feb. 15, 2002. Accessed 19 July 2010.

  2. Jenkins JS, Flaker GC, Nolte B, et al. Causes of higher in-hospital mortality in women than in men after acute myocardial infarction. Am J Cardiol. 1994;73(5):319–22.

    Article  PubMed  CAS  Google Scholar 

  3. Gregg EW, Gu Q, Cheng YJ, Narayan KM, Cowie CC. Mortality trends in men and women with diabetes. Ann Intern Med. 2007;147:149–55.

    PubMed  Google Scholar 

  4. Mosca L, Grundy SM, Judelson D, et al. Guide to preventative cardiology for women. AHA/ACC scientific statement. Circulation. 1999;99:2480–4.

    Article  PubMed  CAS  Google Scholar 

  5. Mosca L, Appel L, Benjamin E, et al. Evidence-based guidelines for cardiovascular disease prevention in women. Circulation. 2004;109:672–93.

    Article  PubMed  Google Scholar 

  6. Steering Committee of the Physicians’ Health Study Research Group. Final report on the aspirin component of the ongoing Physicians’ Health Study. N Engl J Med. 1989;321:129–35.

    Article  Google Scholar 

  7. Ridker PM, Cook NR, LeeI M, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med. 2005;352:1293–304.

    Article  PubMed  CAS  Google Scholar 

  8. Kannel WB, Vokonas PS. Demographics of the prevalence, incidence and management of coronary heart disease in the elderly and in women. Ann Epidemiol. 1992;2(1):5–14.

    Article  PubMed  CAS  Google Scholar 

  9. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289:76–9.

    Article  PubMed  Google Scholar 

  10. Shaw LJ, Sharaf BL, Johnson BD, et al. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health–National Heart, Lung, and Blood Institue-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation. 2006;114:894–904.

    Article  PubMed  Google Scholar 

  11. Alexander KP, Shaw LJ, Delong ER, et al. Value of exercise treadmill testing in women. J Am Coll Cardiol. 1998;32:1657.

    Article  PubMed  CAS  Google Scholar 

  12. Nguyen JT, Berger AB, Duval S, Luepker RV. Gender disparity in cardiac procedures and medication use for acute myocardial infarction. Am Heart J. 2008;155(5):862–8.

    Article  PubMed  Google Scholar 

  13. Shaw LJ, Shaw RE, Bairey Merz CN, et al. Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology – National Cardiovascular Data Registry. Circulation. 2008;117:1787–801.

    Article  PubMed  Google Scholar 

  14. Hochman JS, Tamis JE, Thompson TD, et al. For the global use of strategies to open occluded coronary arteries in acute coronary syndromes IIb investigators. Sex, clinical presentation, and outcome in patients with acute coronary syndromes. N Engl J Med. 1999;341:226–32.

    Article  PubMed  CAS  Google Scholar 

  15. Chugh SS, Uy-Evanado A, Teodorescu C, et al. Women have a lower prevalence of structural heart disease as a precursor to sudden cardiac arrest. J Am Coll Cardiol. 2009;54(22):2006–11.

    Article  PubMed  Google Scholar 

  16. BaireyMerz CN, Johnson BD, Sharaf BL, et al. Hypoestrogenemia of hypothalamic origin and coronary artery disease in women evaluated for suspected ischemia: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol. 2003;41:413–9.

    Article  Google Scholar 

  17. Egan KM, Lawson JA, Fries S, et al. COX-2-derived prostacyclin confers atheroprotection on female mice. Science. 2004;306:1954–7.

    Article  PubMed  CAS  Google Scholar 

  18. Tannebaum C, Barrett-Connor E, Laughlin GA, Platt RW. A longitudinal study of dehydroepiandrosterone sulphate (DHEAS) change in older men and women: the Rancho Bernardo Study. Eur J Endocrinol. 2004;151:717–25.

    Article  Google Scholar 

  19. Matthews KA, Crawford SL, Chae CU, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol. 2009;54:2366–73.

    Article  PubMed  CAS  Google Scholar 

  20. Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986;111:383–90.

    Article  PubMed  CAS  Google Scholar 

  21. Kemp Jr HG. Left ventricular function in patients with the anginal syndrome and normal coronary angiograms. Am J Cardiol. 1973;32:375–6.

    Article  PubMed  Google Scholar 

  22. Panting JR, Gatehouse PD, Grothues F, et al. Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. N Engl J Med. 2002;346:1948–53.

    Article  PubMed  Google Scholar 

  23. Wittstein IS, Thiemann DR, Lima JAC, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352:539–48.

    Article  PubMed  CAS  Google Scholar 

  24. Wong ND, Pio J, Valencia R, et al. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol. 2001;4:109–14.

    Article  PubMed  Google Scholar 

  25. Teragawa H, Fukuda Y, Matsuda K, et al. Relation between C-reactive protein and coronary microvascular endothelial function. Heart. 2004;90(7):750–4.

    Article  PubMed  CAS  Google Scholar 

  26. Reis SE, Holubkov R, Smith AJC, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE Study. Am Heart J. 2001;141(5):735–41.

    Article  PubMed  CAS  Google Scholar 

  27. Rossi R, Nuzzo A, Origliani G, Modena MG. Prognostic role of flow-mediated dilation and cardiac risk factors in post-menopausal women. J Am Coll Cardiol. 2008;51:997–1002.

    Article  PubMed  Google Scholar 

  28. Olson MB, Kelsey SF, Matthews K, et al. Symptoms, myocardial ischaemia, and quality of life in women: results from the NHLBI-sponsored WISE study. Eur Heart J. 2003;24:1506–14.

    Article  PubMed  Google Scholar 

  29. Johnson BD, Bairey Merz CN, Kelsey SF, et al. Persistent chest pain predicts cardiovascular events in women with and without obstructive coronary artery disease: results from the NHLBI-sponsored WISE study. Eur Heart J. 2006;27:1408–15.

    Article  PubMed  Google Scholar 

  30. Robinson JG, Wallace R, Limacher M, et al. Cardiovascular risk in women with non-specific chest pain (from the Women’s Health Initiative Hormone Trials). Am J Cardiol. 2008;102:693–9.

    Article  PubMed  Google Scholar 

  31. Gulati M, Cooper-DeHoff RM, McClure C, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the National Institutes of Health – National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) study and the St. James Women Take Heart (WTH) project. Arch Intern Med. 2009;169:843–50.

    Article  PubMed  Google Scholar 

  32. American Heart Association Web site. 2010. http://www.americanheart.org/downloadable/heart/1236184538758WOMEN.pdf. Accessed 16 July 2010.

  33. Marrugat J, Sala J, Masia R, et al. Mortality differences between men and women following first myocardial infarction. JAMA. 1998;280:1405–9.

    Article  PubMed  CAS  Google Scholar 

  34. Levin RI. The puzzle of aspirin and sex [editorial]. N Engl J Med. 2005;352:1366–8.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiology, Mercy/Unity Medical Centers, Minneapolis, MN, USA

    Margo Tolins-Mejia MD, FACC

Authors
  1. Margo Tolins-Mejia MD, FACC
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Correspondence to Margo Tolins-Mejia MD, FACC .

Editor information

Editors and Affiliations

  1. Edgcumbe Place 6, St. Paul, 55116, Minnesota, USA

    Zeev Vlodaver

  2. University of Minnesota, Delaware Street S.E. 420, Minneapolis, 55455, Minnesota, USA

    Robert F. Wilson

  3. 4-112 Nils Hasselmo Hall, University of Minnesota, Church Street S.E. 312, Minneapolis, 55455, Minnesota, USA

    Daniel J. Garry

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Tolins-Mejia, M. (2012). Cardiovascular Disease in Women. In: Vlodaver, Z., Wilson, R., Garry, D. (eds) Coronary Heart Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1475-9_28

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  • DOI: https://doi.org/10.1007/978-1-4614-1475-9_28

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-1474-2

  • Online ISBN: 978-1-4614-1475-9

  • eBook Packages: MedicineMedicine (R0)

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