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Cardiac Development and Congenital Heart Disease

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Coronary Heart Disease

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Abstract

The heart is a dynamic organ that pumps more than two billion beats in the average lifetime. It is the first organ to develop during embryogenesis and requires a complex interaction of signaling factors, transcriptional networks, and microRNAs to regulate discrete stages of cardiac specification, differentiation, chamber formation, and growth. Spontaneous genetic mutations in humans and engineered molecular mutations in model systems have improved our understanding of cardiac development in both the human and nonprimate heart. While congenital heart disease (CHD) is relatively common and can be life-threatening, emerging therapies including catheter-based interventions, surgical repair, cellular repair, and cell therapy are improving survival and resulting in increased numbers of adults living with heart disease. Better understanding the mechanisms that govern cardiac development can clarify the pathology of CHD and help develop new therapies for this patient population.

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Authors and Affiliations

  1. Division of Pediatric Cardiology, University of Minnesota Amplatz Children’s Hospital, Minneapolis, MN, USA

    Jamie L. Lohr MD

  2. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, MN, USA

    Cindy M. Martin MD & Daniel J. Garry MD, PhD

Authors
  1. Jamie L. Lohr MD
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  2. Cindy M. Martin MD
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  3. Daniel J. Garry MD, PhD
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Correspondence to Jamie L. Lohr MD .

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Editors and Affiliations

  1. Edgcumbe Place 6, St. Paul, 55116, Minnesota, USA

    Zeev Vlodaver

  2. University of Minnesota, Delaware Street S.E. 420, Minneapolis, 55455, Minnesota, USA

    Robert F. Wilson

  3. 4-112 Nils Hasselmo Hall, University of Minnesota, Church Street S.E. 312, Minneapolis, 55455, Minnesota, USA

    Daniel J. Garry

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Lohr, J.L., Martin, C.M., Garry, D.J. (2012). Cardiac Development and Congenital Heart Disease. In: Vlodaver, Z., Wilson, R., Garry, D. (eds) Coronary Heart Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1475-9_2

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  • DOI: https://doi.org/10.1007/978-1-4614-1475-9_2

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