Abstract
Nanotechnology deals with particles/materials having at least one dimension of size in the range of 1–100 nm. Such particles/materials are generally termed as nanoparticles (NPs), nanochemicals or nanomaterials (NMs). Hence, nanotechnology involves the synthesis of NPs and NMs and their manipulation to generate materials or devices that are used for various applications (Kumar and Yadav 2009; Mohanpuria et al. 2008). Nanotechnology is one of the fastest growing fields, and has a wide range of industrial, medical, agricultural, and military applications (Jaiswal and Simon 2004; Nel et al. 2006; Kumar and Yadav 2009). Because of the breadth of such applications, the production of NPs is increasing daily, and investments in nanotechnology are increasing rapidly worldwide. The annual global production of NPs is expected to reach 104–105 tons (t) per year, after 2010 (Science Policy Section 2004). It has been estimated that nanotechnology-based products will constitute a $1 trillion business by the year 2015. About two million workers would be required to achieve this expected economic goal.
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Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y (2008) DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 233:404–410
Akhtar MJ, Ahamed M, Kumar S, Siddiqui H, Patil G, Ashquin M, Ahmad I (2010) Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells. Toxicology 276:95–102
Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD (2009) Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects. Small 5:701–708
Amaral M, Gomes PS, Lopes MA, Santos JD, Silva RF, Fernandes MH (2009) Cytotoxicity evaluation of nanocrystalline diamond coatings by fibroblast cell cultures. Acta Biomater 5:755–763
Arora S, Jain J, Rajwade JM, Paknikar KM (2008) Cellular responses induced by silver nanoparticles: in vitro studies. Toxicol Lett 179:93–100
Asakura M, Sasaki T, Sugiyama T, Takaya M, Koda S, Nagano K, Arito H, Fukushima S (2010) Genotoxicity and cytotoxicity of multi-wall carbon nanotubes in cultured Chinese hamster lung cells in comparison with chrysotile A fibers. J Occup Health 52:155–166
Aschberger K, Johnston HJ, Stone V, Aitken RJ, Hankin SM, Peters SA, Tran CL, Christensen FM (2010) Review of carbon nanotubes toxicity and exposure-appraisal of human health risk assessment based on open literature. Crit Rev Toxicol 40:759–790
Auffan M, Rose J, Wiesner MR, Bottero JY (2009) Chemical stability of metallic nanoparticles: a parameter controlling their potential cellular toxicity in vitro. Environ Pollut 157:1127–1133
Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch ER, Snyder SE, Yan B (2010) Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Nat Nanotechnol 5:683–689
Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS (2004) Non invasive imaging of quantum dots in mice. Bioconjug Chem 15:79–86
Bastian S, Busch W, Kuhnel D, Springer A, Meißssner T, Holke R, Scholz S, Iwe M, Pompe W, Gelinsky M, Potthoff A, Richter V, Ikonomidou H, Schirmer K (2009) Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro. Environ Health Perspect 117:530–536
Bellucci S, Chiaretti M, Cucina A, Carru GA, Chiaretti AI (2009) Multiwalled carbon nanotube buckypaper: toxicology and biological effects in vitro and in vivo. Nanomedicine 4:531–540
Besov AS, Krivova NA, Vorontsov AV, Zaeva OB, Kozlov DV, Vorozhtsov AB, Parmon VN, Sakovich GV, Komarov VF, Smirniotis PG, Eisenreich N (2010) Air detoxification with nanosize TiO2 aerosol tested on mice. J Hazard Mater 173:40–46
Bianco A, Hoebeke J, Godefroy S, Chaloin O, Pantarotto D, Briand JP, Muller S, Prato M, Partidos CD (2005a) Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties. J Am Chem Soc 127:58–59
Bianco A, Kostarelos K, Prato M (2005b) Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 9:674–679
Blinova I, Ivask A, Heinlaan M, Mortimer M, Kahru A (2010) Ecotoxicity of nanoparticles of CuO and ZnO in natural water. Environ Pollut 158:41–47
Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, Bergamaschi A, Mustelin T (2006) Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett 160:121–126
Bregoli L, Chiarini F, Gambarelli A, Sighinolfi G, Gatti AM, Santi P, Martelli AM, Cocco L (2009) Toxicity of antimony trioxide nanoparticles on human hematopoietic progenitor cells and comparison to cell lines. Toxicology 262:121–129
Brunner TJ, Wick P, Manser P, Spohn P, Grass RN, Limbach LK, Bruinink A, Stark WJ (2006) In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 40:4374–4381
Canesi L, Fabbri R, Gallo G, Vallotto D, Marcomini A, Pojana G (2010) Biomarkers in Mytilus galloprovincialis exposed to suspensions of selected nanoparticles (nano carbon black, C60 fullerene, nano-TiO2, nano-SiO2). Aquat Toxicol 100:168–177
Carrero-Sanchez JC, Elias AL, Mancilla R, Arrellin G, Terrones H, Laclette JP, Terrones M (2006) Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen. Nano Lett 6:1609–1616
Cha KE, Heejoon M (2007) Cytotoxic effects of nanoparticles assessed in vitro and in vivo. J Microbiol Biotechnol 17:1573–1578
Chadeau E, Oulahal N, Dubost L, Favergeon F, Degraeve P (2010) Anti-Listeria innocua activity of silver functionalised textile prepared with plasma technology. Food Control 21:505–512
Chang JS, Chang KLB, Hwang DF, Kong ZL (2007) In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ Sci Technol 41:2064–2068
Chen Z, Meng H, Xing G, Chen C, Zhao Y, Jia G, Wang T, Yuan H, Ye C, Zhao F, Chai Z, Zhu C, Fang X, Ma B, Wan L (2006) Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett 163:109–120
Cheng J, Flahaut E, Cheng SH (2007) Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos. Environ Toxicol Chem 26:708–716
Cho SJ, Maysinger D, Jain M, Roder B, Hackbarth S, Winnik FM (2007) Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir 23:1974–1980
Cho WS, Cho M, Jeong J, Choi M, Cho HY, Han BS, Kim SH, Kim HO, Lim YT, Chung BH, Jeong J (2009a) Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 236:16–24
Cho WS, Kim S, Han BS, Son WC, Jeong J (2009b) Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100 nm-sized PEG-coated gold nanoparticles. Toxicol Lett 191:96–102
Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Ipe BI, Bawendi MG, Frangioni JV (2007) Renal clearance of nanoparticles. Nat Biotechnol 25:1165–1170
Choi SJ, Oh JM, Choy JH (2009) Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells. J Inorg Biochem 103:463–471
Clift MJD, Rothen-Rutishauser B, Brown DM, Duffin R, Donaldson K, Proudfoot L, Guy K, Stone V (2008) The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line. Toxicol Appl Pharmacol 232:418–427
Colognato R, Bonelli A, Ponti J, Farina M, Bergamaschi E, Sabbioni E, Migliore L (2008) Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. Mutagenesis 23:377–382
Cui D, Tian F, Ozkan CS, Wang M, Gao H (2005) Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol Lett 155:73–85
Deng X, Jia G, Wang H, Sun H, Wang X, Yang S, Wang T, Liu Y (2007) Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon 45:1419–1424
Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18
Drobne D, Jemec A, Tkalec ZP (2009) In vivo screening to determine hazards of nanoparticles: nanosized TiO2. Environ Pollut 157:1157–1164
Eom HJ, Choi J (2009) Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicol In Vitro 23:1326–1332
Fahmy B, Cormier SA (2009) Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicol In Vitro 23:1365–1371
Fiorito S, Serafino A, Andreola F, Bernier P (2006) Effects of fullerenes and single-wall carbon nanotubes on murine and human macrophages. Carbon 44:1100–1105
Fitzpatrick JAJ, Andreko SK, Ernst LA, Waggoner AS, Ballou B, Bruchez MP (2009) Long-term persistence and spectral blue shifting of quantum dots in vivo. Nano Lett 9:2736–2741
Gagne F, Auclair J, Turcotte P, Fournier M, Gagnon C, Sauve S, Blaise C (2008) Ecotoxicity of CdTe quantum dots to freshwater mussels: impacts on immune system, oxidative stress and genotoxicity. Aquat Toxicol 86:333–340
Gannon CJ, Patra CR, Bhattacharya R, Mukherjee P, Curley SA (2008) Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells. J Nanobiotechnol 6:2
Gao X, Yang L, Petros JA, Marshall FF, Simons JW, Nie S (2005) In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotechnol 16:63–72
Goodman CM, McCusker CD, Yilmaz T, Rotello VM (2004) Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 15:897–900
Griffitt RJ, Weil R, Hyndman KA, Denslow ND, Powers K, Taylor D, Barber DS (2007) Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio). Environ Sci Technol 41:8178–8186
Guangping X, Jiao S, Gaoren Z, Liyi S, Dawei Z (2010) Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Arch Toxicol 84:183–190
Gurr JR, Wang ASS, Chen CH, Jan KY (2005) Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213:66–73
Hamasaki T, Kashiwagi T, Imada T, Nakamichi N, Aramaki S, Toh K, Morisawa S, Shimakoshi H, Hisaeda Y, Shirahata S (2008) Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles. Langmuir 24:7354–7364
Hamilton RF, Wu N, Porter D, Buford M, Wolfarth M, Holian A (2009) Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity. Part Fibre Toxicol 6:35
Harrison P (ed) (2007) Emerging challenges: nanotechnology and the environment. In: GEO Year Book 2007. United Nations Environment Programme (UNEP), Nairobi, Kenya, pp 61–68
Helfenstein M, Miragoli M, Rohr S, Muller L, Wick P, Mohr M, Gehr P, Rothen-Rutishauser B (2008) Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Toxicology 253:70–78
Helland A, Scheringer M, Siegrist M, Kastenholz HG, Wiek A, Scholz RW (2008) Risk assessment of engineered nanomaterials: a survey of industrial approaches. Environ Sci Technol 42:640–646
Herzog E, Casey A, Lyng FM, Chambers G, Byrne HJ, Davoren M (2007) A new approach to the toxicity testing of carbon-based nanomaterials-the clonogenic assay. Toxicol Lett 174:49–60
Herzog E, Byrne HJ, Davoren M, Casey A, Duschl A, Oostingh GJ (2009) Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples. Toxicol Appl Pharmacol 236:276–281
Hildebrand H, Kuhnel D, Potthoff A, Mackenzie K, Springer A, Schirmer K (2010) Evaluating the cytotoxicity of palladium/magnetite nano-catalysts intended for wastewater treatment. Environ Pollut 158:65–73
Huang H, Pierstorff E, Osawa E, Ho D (2007) Active nanodiamond hydrogels for chemotherapeutic delivery. Nano Lett 7:3305–3314
Huang BR, Chen PY, Huang CY, Jung SM, Ma YH, Wu T, Chen JP, Wei KC (2009a) Bioavailability of magnetic nanoparticles to the brain. J Magn Magn Mater 321:1604–1609
Huang S, Chueh PJ, Lin YW, Shih TS, Chuang SM (2009b) Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure. Toxicol Appl Pharmacol 241:182–194
Huang CC, Aronstam RS, Chen DR, Huang YW (2010) Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol In Vitro 24:45–55
Huczko A, Lange H (2001) Carbon nanotubes: experimental evidence for a null risk of skin irritation and allergy. Fuller Sci Tech 9:247–250
Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE (2010) Reconstituting organ-level lung functions on a chip. Science 328:1662–1668
Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ (2005) In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 19:975–983
Hussain SM, Javorina AK, Schrand AM, Duhart HM, Ali SF, Schlager JJ (2006) The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. Toxicol Sci 92:456–463
Ispas C, Andreescu D, Patel A, Goia DV, Andreescu S, Wallace KN (2009) Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish. Environ Sci Technol 43:6349–6356
Jaiswal JK, Simon SM (2004) Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol 14:497–504
Jan E, Byrne SJ, Cuddihy M, Davies AM, Volkov Y, Gunko YK, Kotov NA (2008) High-content screening as a universal tool for fingerprinting of cytotoxicity of nanoparticles. ACS Nano 2:928–938
Ji Z, Zhang D, Li L, Shen X, Deng X, Dong L, Wu M, Liu Y (2009) The hepatotoxicity of multi-walled carbon nanotubes in mice. Nanotechnology 20:445101
Jia G, Wang H, Yan L, Wang X, Pei R, Yan T, Zhao Y, Guo X (2005) Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 39:1378–1383
Jin Y, Kannan S, Wu M, Zhao JX (2007) Toxicity of luminescent silica nanoparticles to living cells. Chem Res Toxicol 20:1126–1133
Kagan VE, Tyurina YY, Tyurin VA, Konduru NV, Potapovich AI, Osipov AN, Kisin ER, Schwegler-Berry D, Mercer R, Castranova V, Shvedova AA (2006) Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron. Toxicol Lett 165:88–100
Kang SJ, Kim BM, Lee YJ, Hong SH, Chung HW (2009) Titanium dioxide nanoparticles induce apoptosis through the JNK/p38-caspase-8-Bid pathway in phytohemagglutinin-stimulated human lymphocytes. Biochem Biophys Res Commun 386:682–687
Karakoti AS, Hench LL, Seal S (2006) The potential toxicity of nanomaterials – the role of surfaces. J Manage 58:77–82
Karlsson HL, Cronholm P, Gustafsson J, Moller L (2008) Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chem Res Toxicol 21:1726–1732
Khan JA, Pillai B, Das TK, Singh Y, Maiti S (2007) Molecular effects of uptake of gold nanoparticles in HeLa cells. Chembiochem 8:1237–1240
Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY (2009) Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro 23:1076–1084
Kirchner C, Liedl T, Kudera S, Pellegrino T, Javier AM, Gaub HE, Stolzle S, Fertig N, Parak WJ (2005) Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 5:331–338
Kobayashi N, Naya M, Endoh S, Maru J, Yamamoto K, Nakanishi J (2009) Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: different short- and long-term post-instillation results. Toxicology 264:110–118
Koeneman BA, Zhang Y, Hristovski K, Westerhoff P, Chen Y, Crittenden JC, Capco DG (2009) Experimental approach for an in vitro toxicity assay with non-aggregated quantum dots. Toxicol In Vitro 23:955–962
Koike E, Kobayashi T (2006) Chemical and biological oxidative effects of carbon black nanoparticles. Chemosphere 65:946–951
Kolosnjaj J, Szwarc H, Moussa F (2007) Toxicity studies of fullerenes and derivatives. Adv Exp Med Biol 620:168–180
Komatsu T, Tabata M, Kubo-Irie M, Shimizu T, Suzuki KI, Nihei Y, Takeda K (2008) The effects of nanoparticles on mouse testis Leydig cells in vitro. Toxicol In Vitro 22:1825–1831
Kuhnel D, Busch W, Meißner T, Springer A, Potthoff A, Richter V, Gelinsky M, Scholz S, Schirmer K (2009) Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line. Aquat Toxicol 93:91–99
Kumar V, Yadav SK (2009) Plant-mediated synthesis of silver and gold nanoparticles and their applications. J Chem Technol Biotechnol 84:151–157
Lai JCK, Lai MB, Jandhyam S, Dukhande VV, Bhushan A, Daniels CK, Leung SW (2008) Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts. Int J Nanomed 3:533–545
Lam CW, James JT, McCluskey R, Hunter RL (2004) Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126–134
Lee HY, Park HK, Lee YM, Kim K, Park SB (2007a) A practical procedure for producing silver nanocoated fabric and its antibacterial evaluation for biomedical applications. Chem Commun 28:2959–2961
Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, Xu XHN (2007b) In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1:133–143
Lee HM, Shin DM, Song HM, Yuk JM, Lee ZW, Lee SH, Hwang SM, Kim JM, Lee CS, Jo EK (2009) Nanoparticles up-regulate tumor necrosis factor-α and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation. Toxicol Appl Pharmacol 238:160–169
Lei R, Wu C, Yang B, Ma H, Shi C, Wang Q, Wang Q, Yuan Y, Liao M (2008) Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity. Toxicol Appl Pharmacol 232:292–301
Li F, Zhou X, Zhu J, Ma J, Huang X, Wong ST (2007a) High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles. BMC Biotechnol 7:66
Li J, Tang S, Lu L, Zeng HC (2007b) Preparation of nanocomposites of metals, metal oxides, and carbon nanotubes via self-assembly. J Am Chem Soc 129:9401–9409
Li SQ, Zhu RR, Zhu H, Xue M, Sun XY, Yao SD, Wang SL (2008) Nanotoxicity of TiO2 nanoparticles to erythrocyte in vitro. Food Chem Toxicol 46:3626–3631
Lin W, Huang YW, Zhou XD, Ma Y (2006) In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 217:252–259
Lindberg HK, Falck GCM, Suhonen S, Vippola M, Vanhala E, Catalan J, Savolainen K, Norppa H (2009) Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro. Toxicol Lett 186:166–173
Liu X, Sun J (2010) Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kB pathways. Biomaterials 31:8198–8209
Liu KK, Cheng CL, Chang CC, Chao JI (2007) Biocompatible and detectable carboxylated nanodiamond on human cell. Nanotechnology 18:325102
Liu Z, Davis C, Cai W, He L, Chen X, Dai H (2008) Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci USA 105:1410–1415
Liu Z, Ren G, Zhang T, Yang Z (2009) Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles. Toxicology 264:179–184
Lovern SB, Strickler JR, Klaper R (2007) Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (titanium dioxide, nano-C60, and C60HxC70Hx). Environ Sci Technol 41:4465–4470
Lu S, Duffin R, Poland C, Daly P, Murphy F, Drost E, MacNee W, Stone V, Donaldson K (2009) Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation. Environ Health Perspect 117:241–247
Magrez A, Kasas S, Salicio V, Pasquier N, Seo JW, Celio M, Catsicas S, Schwaller B, Forro L (2006) Cellular toxicity of carbon-based nanomaterials. Nano Lett 6:1121–1125
Magrez A, Horvath L, Smajda R, Salicio V, Pasquier N, Forro L, Schwaller B (2009) Cellular toxicity of TiO2-based nanofilaments. ACS Nano 3:2274–2280
Mahmoudi M, Simchi A, Milani AS, Stroeve P (2009) Cell toxicity of superparamagnetic iron oxide nanoparticles. J Colloid Interface Sci 336:510–518
Ma-Hock L, Treumann S, Strauss V, Brill S, Luizi F, Mertler M, Wiench K, Gamer AO, Ravenzwaay BV, Landsiedel R (2009) Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol Sci 112:468–481
Meng H, Chen Z, Xing G, Yuan H, Chen C, Zhao F, Zhang C, Wang Y, Zhao Y (2007a) Ultrahigh reactivity and grave nanotoxicity of copper nanoparticles. J Radioanal Nucl Chem 272:595–598
Meng H, Chen Z, Xing G, Yuan H, Chen C, Zhao F, Zhang C, Zhao Y (2007b) Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles. Toxicol Lett 175:102–110
Miller RJ, Lenihan HS, Muller EB, Tseng N, Hanna SK, Keller AA (2010) Impacts of metal oxide nanoparticles on marine phytoplankton. Environ Sci Technol 44:7329–7334
Moghimi SM, Hunter AC, Murray JC (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53:283–318
Mohan N, Chen CS, Hsieh HH, Wu YC, Chang HC (2010) In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans. Nano Lett 10:3692–3699
Mohanpuria P, Rana NK, Yadav SK (2008) Biosynthesis of nanoparticles: technological concepts and future applications. J Nanopart Res 10:507–517
Moos PJ, Chung K, Woessner D, Honeggar M, Cutler NS, Veranth JM (2010) ZnO particulate matter requires cell contact for toxicity in human colon cancer cells. Chem Res Toxicol 23:733–739
Murphy CJ, Gole AM, Stone JW, Sisco PN, Alkilany AM, Goldsmith EC, Baxter SC (2008) Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc Chem Res 41:1721–1730
Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627
Nelson SM, Mahmoud T, Miles B, Shapiro P, Mcllroy DN, Stenkamp DL (2010) Toxic and teratogenic silica nanowires in developing vertebrate embryos. Nanomed Nanotechnol 6:93–102
Nowack B, Bucheli TD (2007) Occurrence, behavior and effects of nanoparticles in the environment. Environ Pollut 150:5–22
Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, L David, Olin S, Monteiro-Riviere N, Warheit D, Yang H, A report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group (2005a) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2:8
Oberdörster G, Oberdorster E, Oberdorster J (2005b) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839
Oesterling E, Chopra N, Gavalas V, Arzuaga X, Lim EJ, Sultana R, Butterfield DA, Bachas L, Hennig B (2008) Alumina nanoparticles induce expression of endothelial cell adhesion molecules. Toxicol Lett 178:160–166
Papis E, Rossi F, Raspanti M, Dalle-Donne I, Colombo G, Milzani A, Bernardini G, Gornati R (2009) Engineered cobalt oxide nanoparticles readily enter cells. Toxicol Lett 189:253–259
Park EJ, Yi J, Chung KH, Ryu DY, Choi J, Park K (2008) Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol Lett 180:222–229
Park EJ, Yoon J, Choi K, Yi J, Park K (2009) Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicology 260:37–46
Patlolla A, Patlolla B, Tchounwou P (2010) Evaluation of cell viability, DNA damage, and cell death in normal human dermal fibroblast cells induced by functionalized multiwalled carbon nanotube. Mol Cell Biochem 338:225–232
Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK (2007) Cell selective response to gold nanoparticles. Nanomedicine 3:111–119
Pauluhn J (2010) Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci 113:226–242
Pelka J, Gehrke H, Esselen M, Turk M, Crone M, Brase S, Muller T, Blank H, Send W, Zibat V, Brenner P, Schneider R, Gerthsen D, Marko D (2009) Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity. Chem Res Toxicol 22:649–659
Prabhu BM, Ali SF, Murdock RC, Hussain SM, Srivatsan M (2010) Copper nanoparticles exert size and concentration dependent toxicity on somatosensory neurons of rat. Nanotoxicology 4:150–160
Pulskamp K, Diabate S, Krug HF (2007) Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 168:58–74
Rahman MF, Wang J, Patterson TA, Saini UT, Robinson BL, Newport GD, Murdock RC, Schlager JJ, Hussain SM, Ali SF (2009) Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles. Toxicol Lett 187:15–21
Ravenzwaay BV, Landsiedel R, Fabian E, Burkhardt S, Strauss V, Ma-Hock L (2009) Comparing fate and effects of three particles of different surface properties: nano-TiO2, pigmentary TiO2 and quartz. Toxicol Lett 186:152–159
Rice RH, Vidrio EA, Kumfer BM, Qin Q, Willits NH, Kennedy IM, Anastasio C (2009) Generation of oxidant response to copper and iron nanoparticles and salts: stimulation by ascorbate. Chem Biol Interact 181:359–365
Roco MC (2005) International perspective on government nanotechnology funding in 2005. J Nanopart Res 7:707–712
Roh JY, Sim SJ, Yi J, Park K, Chung KH, Ryu DY, Choi J (2009) Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics. Environ Sci Technol 43:3933–3940
Rosas-Hernandez H, Jimenez-Badillo S, Martinez-Cuevas PP, Gracia-Espino E, Terrones H, Terrones M, Hussain SM, Ali SF, Gonzalez C (2009) Effects of 45-nm silver nanoparticles on coronary endothelial cells and isolated rat aortic rings. Toxicol Lett 191:305–313
Rothen-Rutishauser BM, Schurch S, Haenni B, Kapp N, Gehr P (2006) Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ Sci Technol 40:4353–4359
Rouse JG, Haslauer CM, Loboa EG, Monteiro-Riviere NA (2008) Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles. Toxicol In Vitro 22:491–497
Rzigalinski BA, Strobl JS (2009) Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots. Toxicol Appl Pharmacol 238:280–288
Safaepour M, Shahverdi AR, Shahverdi HR, Khorramizadeh MR, Gohari AR (2009) Green synthesis of small silver nanoparticles using Geraniol and its cytotoxicity against Fibrosarcoma-Wehi 164. J Med Biotech 1:111–115
Sayes CM, Reed KL, Warheit DB (2007) Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci 97:163–180
Schrand AM, Dai L, Schlager JJ, Hussain SM, Osawa E (2007a) Differential biocompatibility of carbon nanotubes and nanodiamonds. Diam Relat Mater 16:2118–2123
Schrand AM, Huang H, Carlson C, Schlager JJ, Osawa E, Hussain SM, Dai L (2007b) Are diamond nanoparticles cytotoxic? J Phys Chem B 111:2–7
Science Policy Section (2004) Nanoscience and nanotechnologies: opportunities and uncertainties. The Royal Society and The Royal Academy of Engineering, Clyvedon, London
Sharma V, Shukla RK, Saxena N, Parmar D, Das M, Dhawan A (2009) DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett 185:211–218
Shvedova AA, Castranova V, Kisin ER, Schwegler-Berry D, Murray AR, Gandelsman VZ, Maynard A, Baron P (2003) Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 66:1909–1926
Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini J, Evans DE, Ku BK, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron P (2005) Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698–L708
Simberg D, Zhang WM, Merkulov S, McCrae K, Park JH, Sailor MJ, Ruoslahti E (2009) Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo. J Control Release 140:301–305
Simon-Deckers A, Gouget B, Mayne-L’hermite M, Herlin-Boime N, Reynaud C, Carriere M (2008) In vitro investigation of oxide nanoparticle and carbon nanotube toxicity and intracellular accumulation in A549 human pneumocytes. Toxicology 253:137–146
Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K (2006) Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 103:3357–3362
Smith CJ, Shaw BJ, Handy RD (2007) Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effects. Aquat Toxicol 82:94–109
Strigul N, Vaccari L, Galdun C, Wazne M, Liu X, Christodoulatos C, Jasinkiewicz K (2009) Acute toxicity of boron, titanium dioxide, and aluminum nanoparticles to Daphnia magna and Vibrio fischeri. Desalination 248:771–782
Sun H, Zhang X, Zhang Z, Chen Y, Crittenden JC (2009) Influence of titanium dioxide nanoparticles on speciation and bioavailability of arsenite. Environ Pollut 157:1165–1170
Sung JH, Ji JH, Park JD, Yoon JU, Kim DS, Jeon KS, Song MY, Jeong J, Han BS, Han JH, Chung YH, Chang HK, Lee JH, Cho MH, Kelman BJ, Yu I (2009) Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci 108:452–461
Suwalski A, Dabboue H, Delalande A, Bensamoun SF, Canon F, Midoux P, Saillant G, Klatzmann D, Salvetat JP, Pichon C (2010) Accelerated achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles. Biomaterials 31:5237–5245
Tarantola M, Schneider D, Sunnick E, Adam H, Pierrat S, Rosman C, Breus V, Sonnichsen C, Basche T, Wegener J, Janshoff A (2009) Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility. ACS Nano 3:213–222
Tedesco S, Doyle H, Redmond G, Sheehan D (2008) Gold nanoparticles and oxidative stress in Mytilus edulis. Mar Environ Res 66:131–133
Tian F, Cui D, Schwarz H, Estrada GG, Kobayashi H (2006) Cytotoxicity of single-wall carbon nanotubes on human fibroblasts. Toxicol In Vitro 20:1202–1212
Valant J, Drobne D, Sepcic K, Jemec A, Kogej K, Kostanjsek R (2009) Hazardous potential of manufactured nanoparticles identified by in vivo assay. J Hazard Mater 171:160–165
Vamanu CI, Cimpan MR, Hol PJ, Sornes S, Lie SA, Gjerdet NR (2008) Induction of cell death by TiO2 nanoparticles: studies on a human monoblastoid cell line. Toxicol In Vitro 22:1689–1696
Wan R, Mo Y, Zhang X, Chien S, Tollerud DJ, Zhang Q (2008) Matrix metalloproteinase-2 and −9 are induced differently by metal nanoparticles in human monocytes: the role of oxidative stress and protein tyrosine kinase activation. Toxicol Appl Pharmacol 233:276–285
Wang B, Feng WY, Wang TC, Jia G, Wang M, Shi JW, Zhang F, Zhao YL, Chai ZF (2006) Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice. Toxicol Lett 161:115–123
Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, Jia G, Gao Y, Li B, Sun J, Li Y, Jiao F, Zhao Y, Chai Z (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–185
Wang J, Liu Y, Jiao F, Lao F, Li W, Gu Y, Li Y, Ge C, Zhou G, Li B, Zhao Y, Chai Z, Chen C (2008a) Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicology 254:82–90
Wang S, Lu W, Tovmachenko O, Rai US, Yu H, Ray PC (2008b) Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes. Chem Phys Lett 463:145–149
Wang F, Gao F, Lan M, Yuan H, Huang Y, Liu J (2009a) Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol In Vitro 23:808–815
Wang H, Wick RL, Xing B (2009b) Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans. Environ Pollut 157:1171–1177
Wang Y, Tan S, Wang J, Wu Q, Chen X, Deng X, Lu Q, Wu M (2010) Direct imaging of apoptosis process of neural stem cells exposed to porous silica nanoparticles. Curr Nanosci 6:292–297
Warheit DB, Laurence BR, Reed KL, Roach DH, Reynolds GAM, Webb TR (2004) Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77:117–125
Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, Sayes CM (2007) Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol Lett 171:99–110
Warheit DB, Sayes CM, Reed KL (2009) Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures? Environ Sci Technol 43:7939–7945
Wick P, Manser P, Limbach LK, Dettlaff-Weglikowska U, Krumeich F, Roth S, Stark WJ, Bruinink A (2007) The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 168:121–131
Wiench K, Wohlleben W, Hisgen V, Radke K, Salinas E, Zok S, Landsiedel R (2009) Acute and chronic effects of nano- and non-nano-scale TiO2 and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna. Chemosphere 76:1356–1365
Wiesner MR, Lowry GV, Jones KL, Hochella MF, Giulio RTD, Casman E, Bernhardt ES (2009) Decreasing uncertainties in assessing environmental exposure, risk, and ecological implications of nanomaterials. Environ Sci Technol 43:6458–6462
Wiwanitkit V, Sereemaspun A, Rojanathanes R (2009a) Effect of gold nanoparticle on the microscopic morphology of white blood cell. Cytopathology 20:109–110
Wiwanitkit V, Sereemaspun A, Rojanathanes R (2009b) Effect of gold nanoparticles on spermatozoa: the first world report. Fertil Steril 91:e7–e8
Wu J, Liu W, Xue C, Zhou S, Lan F, Bi L, Xu H, Yang X, Zeng FD (2009) Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191:1–8
Xu JY, Li QN, Li JG, Ran TC, Wu SW, Song WM, Chen SL, Li WX (2007) Biodistribution of 99mTc-C60(OH) x in sprague-dawley rats after intratracheal instillation. Carbon 45:1865–1870
Xu Y, Mahmood M, Li Z, Dervishi E, Trigwell S, Zharov VP, Ali N, Saini V, Biris AR, Lupu D, Boldor D, Biris AS (2008) Cobalt nanoparticles coated with graphitic shells as localized radio frequency absorbers for cancer therapy. Nanotechnology 19:435102
Yamawaki H, Iwai N (2006) Cytotoxicity of water-soluble fullerene in vascular endothelial cells. Am J Physiol Cell Physiol 290:C1495–C1502
Yan L, Zhao F, Li S, Hu Z, Zhao Y (2011) Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes. Nanoscale 3:362–382
Yang ST, Cao L, Luo PG, Lu F, Wang X, Wang H, Meziani MJ, Liu Y, Qi G, Sun YP (2009a) Carbon dots for optical imaging in vivo. J Am Chem Soc 131:11308–11309
Yang ST, Wang X, Wang H, Lu F, Luo PG, Cao L, Meziani MJ, Liu JH, Liu Y, Chen M, Huang Y, Sun YP (2009b) Carbon dots as nontoxic and high-performance fluorescence imaging agents. J Phys Chem C 113:18110–18114
Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z (2010a) Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett 10:3318–3323
Yang Z, Liu ZW, Allaker RP, Reip P, Oxford J, Ahmad Z, Ren G (2010b) A review of nanoparticle functionality and toxicity on the central nervous system. J R Soc Interface 7:S411–S422
Yu SJ, Kang MW, Chang HC, Chen KM, Yu YC (2005) Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity. J Am Chem Soc 127:17604–17605
Yu KO, Grabinski CM, Schrand AM, Murdock RC, Wang W, Gu B, Schlager JJ, Hussain SM (2009) Toxicity of amorphous silica nanoparticles in mouse keratinocytes. J Nanopart Res 11:15–24
Yuan Y, Chen Y, Liu JH, Wang H, Liu Y (2009) Biodistribution and fate of nanodiamonds in vivo. Diam Relat Mater 18:95–100
Zablotskaya A, Segal I, Lukevics E, Maiorov M, Zablotsky D, Blums E, Shestakova I, Domracheva I (2009) Water-soluble magnetic nanoparticles with biologically active stabilizers. J Magn Magn Mater 321:1428–1432
Zhang T, Stilwell JL, Gerion D, Ding L, Elboudwarej O, Cooke PA, Gray JW, Alivisatos AP, Chen FF (2006) Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Lett 6:800–808
Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA (2008) Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol 228:200–211
Zhang Y, Ali SF, Dervishi E, Xu Y, Li Z, Casciano D, Biris AS (2010a) Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano 4:3181–3186
Zhang Y, Hu L, Yu D, Gao C (2010b) Influence of silica particle internalization on adhesion and migration of human dermal fibroblasts. Biomaterials 31:8465–8474
Zhao J, Xu L, Zhang T, Ren G, Yang Z (2009) Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons. Neurotoxicology 30:220–230
Zhu S, Oberdorster E, Haasch ML (2006) Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow. Mar Environ Res 62:S5–S9
Zhu L, Chang DW, Dai L, Hong Y (2007) DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Lett 7:3592–3597
Zhu MT, Feng WY, Wang B, Wang TC, Gu YQ, Wang M, Wang Y, Ouyang H, Zhao YL, Chai ZF (2008) Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology 247:102–111
Zhu X, Wang J, Zhang X, Chang Y, Chen Y (2009) The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio). Nanotechnology 20:195103
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Authors are thankful to the Director, IHBT, for his continuous encouragement and suggestions to pursue research in the stated areas.
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VK would like to acknowledge Council of Scientific and Industrial Research (CSIR), Govt of India for providing research fellowship in the form of SRF. CSIR and DBT, Govt of India are duly acknowledged for financial support to the laboratory.
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Kumar, V., Kumari, A., Guleria, P., Yadav, S.K. (2012). Evaluating the Toxicity of Selected Types of Nanochemicals. In: Whitacre, D. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 215. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1463-6_2
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