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Antibiotic Discovery and Development pp 985–1007Cite as

NMR in Infection Research

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Abstract

In comparison to other research areas, antibacterial drug discovery provides many opportunities to employ nuclear magnetic resonance (NMR) spectroscopy in the process of drug discovery. First of all, there are a large number of validated targets that can be cloned and expressed and their biological function is well understood. Most targets can be over-expressed readily and purified at quantities needed for NMR. Meanwhile, structural information is frequently available for at least one representative of a given target. Furthermore, enzyme substrates and corresponding inhibitors are often available and characterized. In combination, these factors make NMR studies for bacterial targets both feasible and economical in industrial research.

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Author information

Authors and Affiliations

  1. Infection Discovery, AstraZeneca Pharmaceuticals LP, 35 Gatehouse Drive, Waltham, MA, 02451, USA

    Jun Hu & Gunther Kern

Authors
  1. Jun Hu
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  2. Gunther Kern
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Correspondence to Gunther Kern .

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Editors and Affiliations

  1. , Senior Principal Scientist, AstraZeneca Pharmaceuticals LP, Gatehouse Dr. 35, Waltham, 02451, Massachusetts, USA

    Thomas J. Dougherty

  2. Achillion Pharmaceuticals, Inc., George St. 300, New Haven, 06511, Connecticut, USA

    Michael J. Pucci

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Hu, J., Kern, G. (2012). NMR in Infection Research. In: Dougherty, T., Pucci, M. (eds) Antibiotic Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1400-1_32

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